This Project Grant award from the National Cancer Institute's (NCI) Cancer Biology Research program (CFDA 93.396) provides $143,443 to support a Genetically Engineered Rodent Models (GERM) core at Baylor College of Medicine. The GERM core led by the Research Specialist, Dr. Reddy, delivers a range of specialized services to support cancer research programs, including:
- Generating various genetically engineered mouse models using CRISPR/Cas9, gene-targeting, and transgene microinjection techniques
- Providing in vitro fertilization, embryo transfer, and cryopreservation services to rederive and expand existing genetically engineered rodent models
- Conducting genotype analysis and maintenance of genetically engineered rodent model lines
Over the past 5 years, the GERM core has generated over 1,653 knockout, knock-in, and transgenic rodent models that have been essential for the success of NCI-funded cancer research programs at Baylor. This R50 grant award will provide Dr. Reddy with greater autonomy to develop new genome editing technologies and services, such as implementing prime editing and improving conditional allele production, to enhance the GERM core's capabilities in supporting cancer research using mouse, rat, and Nile rat models.
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