This Project Grant award of $363,057 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research to understand the mechanisms of epigenetic memory in human cells. The 5-year project, running from July 1, 2024 to May 31, 2029, will be conducted by the University of California, Berkeley. The research aims to unlock how DNA methylation is established in the human genome and how defects in DNA...
This Project Grant award of $240,750 from the National Institutes of Health (NIH) Office of the Director under the Research Infrastructure Programs (CFDA 93.351) supports the development, validation, and broad dissemination of a new mouse model for targeting brown adipose tissue. The key objectives are to:
Generate a novel CRISPR/Cas9-engineered mouse line that expresses Cre-recombinase under the control of the Ucp1 promoter, allowing for targeted manipulation of mature brown...
The National Institutes of Health (NIH) awarded a $265,500 Project Grant (CFDA 93.351 - Research Infrastructure Programs) to The Jackson Laboratory to rapidly develop a large-scale resource of genetically modified mouse strains. The key objectives are to leverage Prime Editing, a novel CRISPR-based technology, to efficiently insert functional DNA sequences into thousands of mouse genes that are already marked with a standardized tag. This will accelerate the creation of versatile mouse models...
This Project Grant award from the National Institutes of Health (NIH) Research Infrastructure Programs (CFDA 93.351) will support the development of two novel types of mouse models to study human diseases. The total funding amount is $235,500.00 and the award period runs from September 1, 2024 to June 30, 2026.
The first model, known as a "Unilateral Mosaic", will express disease-causing genes on only one side of the lung, creating both disease-prone and disease-resistant tissue...
This federal Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) will fund research to produce an atlas of DNA methylation dynamics during mouse embryonic development. The $654,352 award to Oregon Health & Science University (OHSU) will enable researchers to generate high-resolution, single-cell DNA methylation profiles in 24-hour increments from embryonic day...
This $408,750 project grant awarded by the National Institute of General Medical Sciences (NIGMS) supports research to investigate the role of DNA methylation in controlling retrotransposons and governing adult stem cell fates. The project, titled "Dissecting the Role of DNA Methylation in Controlling Retrotransposons and Governing Adult Stem Cell Fates", will be conducted by the University of Texas MD Anderson Cancer Center over the period of August 1, 2024 to May 31, 2029.
The...
This R35GM154941 Project Grant, awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research to identify the mechanisms that regulate and coordinate the expression of DNA methylation "writer" and "eraser" enzymes to maintain epigenetic homeostasis. The $401,250 award to the University of California, Berkeley will fund a comprehensive study of the gene regulatory mechanisms...
This $1,737,000 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports the development of innovative single-cell genomics technologies for joint analysis of regulatory dynamics and transcriptional states. Key objectives include:
Developing multiomics tools to measure rates of epigenomic changes (DNA methylation, demethylation, oxidative damage, DNA repair) and relate these to...
This National Science Foundation project grant of $610,097 will fund the development of computational tools for analyzing and interpreting DNA methylation under the Biological Sciences program (CFDA 47.074). Awarded to Rice University on March 1, 2022 with a projected completion date of February 28, 2027, this grant will result in a suite of new open-source software tools and databases to enable researchers to better analyze DNA methylation data across experimental technologies and...
This National Science Foundation (NSF) Project Grant award under the Biological Sciences program (CFDA 47.074) provides $900,000 from February 1, 2025 to January 31, 2028 to The Regents of the University of Colorado for a research project titled "Uncovering the Molecular Mechanisms of DNMT1-Mediated Inheritance of Gene Silencing." The project aims to utilize structural biology, biochemistry, and cell biology methods to understand the regulation of the DNA methyltransferase 1 (DNMT1)...