Project Grant R21NS153418
- Federal Cooperative Agreement Summary New York University School of Medicine received a $3.31 million Cooperative Agreement award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), effective June 4, 2025 through May 31, 2027. The award funds research to characterize the vascular pathophysiology underlying amyloid-related imaging abnormalities (ARIA) that develop...
- The National Institute of Neurological Disorders and Stroke awarded The Trustees of Columbia University in the City of New York $126,900 on March 7, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds research to exploit RNA biogenesis, specifically alternative splicing programs, to accelerate maturation of human neurons in vitro and to develop models of age-related tauopathies. The research addresses a fundamental...
- The National Institute of Neurological Disorders and Stroke awarded New York University $247,300 on July 14, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to develop quantitative MRI methods for assessing white matter injury and repair. The project integrates multi-shell, multi-diffusion time MRI with large-scale three-dimensional electron microscopy and quantitative immunofluorescence to establish how diffusion and T2-based...
- The National Institute of Neurological Disorders and Stroke awarded the University of Rochester $264,250 on May 5, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to develop and validate a cre-intersectional viral method for precise opto- and chemo-genetic inactivation of specific cortico-cortical projection pathways in awake non-human primates. The funded research addresses a fundamental challenge in neuroscience: achieving...
- The National Institute on Aging (NIA) awarded a $689,525 Project Grant under the Aging Research Federal Grant Program (CFDA 93.866) to New York University (NYU) to investigate the integration of cell-specific microstructure within long-range brain networks in the macaque monkey. The project aims to disentangle cell-type specific signatures of brain microstructure using in vivo MRI techniques and determine how these signatures vary across individuals. This work will contribute to a...
- The National Institute of Allergy and Infectious Diseases awarded New York University $466,125 on February 3, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate the role of perivascular macrophages in controlling neuroinflammatory disease severity. The research examines how border-associated macrophages (BAM), a resident population in the central nervous system perivascular space, contribute to blood-brain barrier function and limit inflammatory cell...
- The National Institute on Aging awarded New York University $642,063 under the Aging Research program (CFDA 93.866) on January 15, 2026, to investigate gabaergic circuit targets for modulating entorhinal cortex and hippocampal dynamics in Alzheimer's disease. The research examines vasoactive intestinal peptide and cholecystokinin inhibitory neuron microcircuits within hippocampal area CA1, with the hypothesis that modulating activity in these circuits can improve lateral entorhinal cortex–CA1...
- The National Institute of Neurological Disorders and Stroke awarded the Sloan-Kettering Institute for Cancer Research $484,000 on May 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds research characterizing and inhibiting interactions of the alpha-secretase ADAM17 with the neuronal-myelin signaling complex upon spinal cord injury. The study investigates how myelin-associated inhibitors—including...
- The National Institute on Aging awarded The Trustees of Columbia University in the City of New York $452,375 on January 1, 2026, under the Aging Research program (CFDA 93.866) to investigate the role of semaphorin 3A in microglial activation and Alzheimer's disease pathology. The research will determine the functional role and mechanistic basis for semaphorin 3A–mediated regulation of microglial activation in Alzheimer's disease. Building on preliminary findings using human induced pluripotent...
- The National Institute of Neurological Disorders and Stroke, part of the Department of Health and Human Services National Institutes of Health, awarded Albany Medical College $1.951689 million on June 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds investigation of inflammation-resolution pathways to address vascular contributions to cognitive impairment and dementia (VCID) in the context of atherosclerosis....
The National Institute of Neurological Disorders and Stroke awarded New York University $466,125 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to characterize amyloid-related imaging abnormalities (ARIA) and cerebral amyloid angiopathy (CAA) in a squirrel monkey model of sporadic CAA. The award funds research integrating multiparametric MRI, biofluid biomarker analysis, and neuropathological examination to identify diagnostic biomarkers for CAA and ARIA, with particular focus on white matter microstructural changes using diffusion tensor and kurtosis imaging. The study examines archived postmortem brains from geriatric squirrel monkeys with and without ARIA, as well as young squirrel monkeys without CAA pathology, to clarify the relationship between diffusion imaging metrics and neuropathological signatures and assess the utility of diffusion MRI in screening for ARIA and capturing cerebrovascular disease burden. New York University, doing business as New York University School of Medicine, is the recipient. The period of performance runs from September 1, 2026, through August 31, 2028, with place of performance in New York, New York. The assistance type is a Project Grant (R21).
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $466.1k | 9/1/26 |