Project Grant R21NS147229
- This federal Project Grant award of $869,478 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program supports research to understand the cellular and molecular mechanisms of inherited prion diseases. The award will enable researchers at the Trustees of Boston University to generate a library of induced pluripotent stem cells (iPSCs) from members of an Israeli family...
- This Project Grant award, with a total funding amount of $909,090, was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program. The award supports research aimed at developing a therapeutic strategy to treat prion diseases, a rare class of neurodegenerative disorders. Specifically, the grant will fund investigations into a small molecule compound, A5,...
- The National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) grant program, awarded a $481,250 Project Grant to The Broad Institute, Inc. to investigate prion clearance and treatment of recalcitrant prion strains through deep suppression of the prion protein (PrP). The research aims to: 1) quantify the depth of PrP suppression achievable under a repeated dosing regimen, 2) determine the...
- This federal Project Grant award of $386,650 was provided by the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The project aims to define the mechanism of action of a novel anti-prion compound called Elacridar, and to further explore its effects against misfolded proteins associated with other neurodegenerative diseases such as Parkinson's and Alzheimer's. The research...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $628,726 Project Grant under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855) to Priogen Corp. and the University of Minnesota. The funding supports the development of an advanced point-of-care microfluidic device, called Micro-QUIC, that can rapidly detect misfolded prion proteins associated with fatal neurodegenerative Transmissible Spongiform Encephalopathies (TSEs) like...
- This $3,081,936 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to investigate the mechanisms underlying TDP-43 proteinopathies, which are linked to frontotemporal dementia (FTD), amyotrophic lateral sclerosis (ALS), and other neurodegenerative diseases. The research will utilize a multimodal MERFISH (multiplexed...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $168,321 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to the Regents of the University of Michigan. The grant, titled "Investigating Mechanisms of NPC1 Proteostasis in Human Neurons", aims to determine the effectors mediating NPC1 folding, trafficking, and degradation in neurons for Niemann-Pick disease type C, a rare lysosomal storage...
- The Project Grant award of $698,390, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853), supports research to harness innate immunity to control the neuroinflammatory HIV reservoir. The research aims to investigate how HIV-1 infection triggers an interferon (IFN) response and how IFN-β can be used in conjunction with combined anti-retroviral therapy (cART) to restrict...
- This $897,250 Project Grant awarded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) will support research by St. Jude Children's Research Hospital Inc. to investigate the role of biomolecular condensates in neurological diseases. The research program aims to address outstanding questions regarding the physiological functions of biomolecular condensates, how they establish...
- This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) seeks to develop a next-generation preclinical model of NeuroHIV that better recapitulates neuro-immune-vascular system interactions in the context of ART-mediated HIV suppression. The $1,025,015 award to the Scintillon Institute, a non-profit biomedical research organization in San Diego,...
This $429,000 Project Grant awarded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program aims to investigate the pathogenic mechanisms underlying Creutzfeldt-Jakob disease (CJD), a rapidly progressive dementia caused by misfolded prion proteins. The research will focus on: 1) structural analysis of pathogenic versus non-pathogenic prion protein fibrils using cryo-electron microscopy; 2) examining differential glial cell responses to pathogenic and non-pathogenic prion fibrils; and 3) investigating anti-prion mechanisms of non-pathogenic recombinant prion protein fibrils. This work is being conducted by the University of Texas Health Science Center at Houston, a state-controlled institution of higher learning with expertise in advanced medical and scientific research, from September 2025 through August 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $429.0k | 9/23/25 |