Project Grant R21NS146869
- Federal Grant Award Summary The University of Virginia received a $242,250 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, effective February 1, 2026 through January 31, 2028. This award supports a two-year investigative research project examining myeloid cell regulation of cerebrovascular tone in the brain, with research activities...
- Federal Grant Award Summary The University of Virginia received a $188,237 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, effective August 5, 2025, through July 31, 2030. This award supports the Epilepsy Training Program (ETP), which delivers comprehensive workforce development and research training designed to prepare the next generation...
- Federal Grant Award Summary The University of California, San Diego received a $521,839 Project Grant award from the National Institute of Neurological Disorders and Stroke under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, effective August 7, 2025, with completion targeted for July 31, 2030. This five-year research initiative will investigate the mechanisms of pathogenic microglial populations in central nervous system (CNS)...
- Federal Grant Award Summary The University of Virginia received a $444,125 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), awarded August 1, 2025, with a completion date of June 30, 2030. This award supports fundamental research to unravel the mechanisms of protein sorting and localization to organelles, specifically investigating how nascent protein chains are processed and folded during...
- Federal Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded the University of Virginia a Project Grant of $353,430 on September 15, 2025, under the Biomedical Research and Research Training program (CFDA 93.859) to support investigator-initiated basic research through July 31, 2029. This award funds fundamental research into the regulation of ceramide-1-phosphate (C1P) metabolism and its role in cellular signaling networks, specifically examining how C1P...
- Federal Grant Award Summary The University of Virginia received a $759,095 Project Grant award from the National Institute on Aging (Aging Research program, CFDA 93.866) on May 15, 2025, with completion targeted for February 28, 2030. The award funds research and development of magnetic resonance (MR) image-guided focused ultrasound (FUS) technology combined with microbubbles to selectively deliver SHIP-1 neutralizing therapies across the blood-brain barrier to brain-resident microglia. The...
- Federal Project Grant Award Summary The University of Virginia received a $444,125 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), effective July 18, 2025, with a completion date of June 30, 2027. This research project investigates the role of progesterone receptors (PRs) in regulating the transition from episodic migraine (EM) to chronic...
- Federal Grant Award Summary Vanderbilt University received a $103,449 Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), awarded December 1, 2025, with a completion date of May 31, 2027. The research project, titled "Patient-Centered Neurological Evaluation of Functional MRI Outcomes in Multiple Sclerosis," will develop and validate...
- Federal Grant Award Summary The University of Virginia received a $847,875 Project Grant from the Defense Health Agency under the Military Medical Research and Development program (CFDA 12.420) for the period of September 1, 2025, through August 31, 2028. This award supports research targeting Schwann cell-tumor microenvironment interactions in neurofibroma development, conducted at the institution's Charlottesville, Virginia location. The project advances the Defense Health Agency's mission...
- Federal Grant Award Summary The University of Virginia received a $400,530 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective June 1, 2025, through March 31, 2030. This award supports the development of advanced nanodisc technology platforms designed to investigate membrane protein-lipid interactions and their role in cellular signaling and physiology. The research will focus on...
The University of Virginia received a $236,896 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) for research conducted in Charlottesville, Virginia. The award, dated February 1, 2026, with completion targeted for January 31, 2028, funds basic neuroscience research exploring the link between enteric glial cells (EGCs) and multiple sclerosis (MS) etiology. The research investigates the hypothesis that EGCs in the gastrointestinal tract, which express myelin proteins targeted in MS patients and possess immune response capabilities, may play a role in initiating MS disease pathology. The project delivers scientific investigation and experimental research services aimed at understanding MS disease mechanisms through cellular and molecular analysis of the enteric nervous system. Research activities include characterization of EGC myelin transcript expression, evaluation of antigen presentation capabilities, assessment of EGC activation in MS disease models, and selective ablation studies using novel animal models. The research addresses a significant public health need, as MS affects over one million Americans and gastrointestinal symptoms precede MS diagnosis in approximately one-third of patients, suggesting a potential gut-related contribution to disease initiation.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $236.9k | 1/22/26 |