Project Grant R21NS146806
- Federal Grant Award Summary The University of Texas Southwestern Medical Center received a $656,879 Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, effective August 1, 2025, through July 31, 2030. The award supports fundamental research investigating the mechanisms of glioma initiation by isocitrate dehydrogenase (IDH) oncogenes in lower and...
- Federal Project Grant Award Summary The University of Texas Southwestern Medical Center received a $1.476 million project grant awarded September 1, 2025, through the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310). The three-year award (concluding August 31, 2028) supports investigator-initiated research focused on disentangling molecular networks in ribonucleic acid (RNA) homeostasis and neuromuscular diseases. The project...
- Federal Project Grant Award Summary The University of Texas Southwestern Medical Center received a $451,000 Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) for the period August 1, 2025 through July 31, 2027. The award funds research on in vivo neuronal reprogramming of fibroblasts following spinal cord injury (SCI), addressing the significant...
- Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded $870,560 to the University of Texas Medical Branch at Galveston under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, effective March 1, 2025, with a completion date of December 31, 2029. This Project Grant supports basic neuroscience research investigating membrane-remodeling factors that regulate oligodendroglial cell structure and...
- Federal Grant Award Summary The University of Massachusetts Medical School received a $659,245 Project Grant award, effective March 1, 2026 through February 28, 2031, from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). This award supports the development of a gene therapy treatment for UBA5 (Ubiquitin Like Modifier Activating Enzyme 5) deficiency, an ultra-rare...
- Federal Grant Award Summary The University of Texas Health Science Center at Houston received a $429,000 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, awarded on September 22, 2025, with a completion date of August 31, 2027. The research initiative investigates the pathogenic mechanisms of Creutzfeldt-Jakob Disease (CJD) and other prion...
- Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $2.66 million Project Grant to The Regents of the University of California, San Francisco on February 15, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award supports a five-year research initiative extending through January 31, 2031, focused on discovering and validating delivery vectors for gene therapies and...
- Federal Grant Award Summary The University of Texas Southwestern Medical Center received a $451,000 Project Grant award from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310), effective July 1, 2025 through June 30, 2027. This R21 exploratory grant funds research to develop CRISPR interference (CRISPRi) technology tools and high-throughput screening methodologies for identifying genes on human chromosome 21 (HSA21) that...
- Federal Project Grant Award Summary The University of Texas Southwestern Medical Center received a $151,040 Project Grant from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), awarded on April 15, 2026, with a completion date of November 30, 2028. The research initiative, titled "Development of Muscle Optimized Non-Viral Gene Editors," focuses on advancing treatment...
- Federal Grant Award Summary The Ohio State University received a $499,452 Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, with an award date of May 15, 2025, and completion date of April 30, 2030. This award supports fundamental research investigating the disease mechanisms of Charcot-Marie-Tooth Disease Type 2E (CMT2E) and the development of...
The University of Texas Southwestern Medical Center received a $249,000 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The award, issued on February 15, 2026, with a completion date of January 31, 2028, funds research into gene replacement therapy for Charcot-Marie-Tooth (CMT) neuropathies caused by GDAP1 gene mutations. The research will utilize adeno-associated virus 9 (AAV9) vectors to deliver the GDAP1 gene to spinal cord neurons and Schwann cells in newly characterized rat models (GDAP1 knockout and knockin lines) to evaluate the dose-responsive safety and efficacy of AAV9/GDAP1 treatment. The primary deliverables include comprehensive preclinical research evaluating AAV9-mediated gene replacement therapy in CMT4A (severe, early-onset) and CMT2K (milder, late-onset) disease models. The research involves both short-term and long-term studies assessing transgene expression, toxicity monitoring, and efficacy measures in rats treated at presymptomatic (2.5 months) and symptomatic (12 months) developmental stages. This foundational research is expected to generate critical safety and efficacy data necessary to support future clinical translation of gene replacement therapy for CMT4A and CMT2K patients.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $249.0k | 2/13/26 |