Project Grant R21NS146763
- The National Institute of Neurological Disorders and Stroke awarded Beth Israel Deaconess Medical Center, Inc. $283,037 on August 15, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds exploratory research investigating the relationship between meningeal nociception and visual cortex hyperexcitability in migraine pathogenesis. The project employs optogenetic activation of meningeal nociceptors, two-photon calcium...
- The National Institute of Neurological Disorders and Stroke, part of the National Institutes of Health, awarded Beth Israel Deaconess Medical Center $749,073 on August 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate meningeal sensory neuroimmune interactions underlying migraine headache. The research combines expertise in meningeal nociception and migraine pain with functional interactions between nociceptors...
- The National Institutes of Health Office of the Director awarded Beth Israel Deaconess Medical Center $2,074,796 on September 15, 2025, under Trans-NIH Research Support (CFDA 93.310) to investigate orexin neuropeptides and their role in menopausal symptom severity using a mouse model. The research examines how chronically low estradiol in postmenopausal states elevates orexin neuron activity in the hypothalamus, leading to increased sleep disruption and vasomotor responses such as hot flashes....
- The National Institute of Neurological Disorders and Stroke awarded the University of Massachusetts Medical School $460,625 on August 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate time-dependent membrane proteomics in circadian pacemaker neurons. The recipient will use cutting-edge proteomic approaches combined with biotin proximity labeling to survey the membrane proteome of circadian neurons during the...
- The National Institute of Neurological Disorders and Stroke awarded Boston Children's Hospital $711,952 under Project Grant R01NS144151 on May 2, 2026, to investigate circadian regulation of synaptic function and sleep-wake behavior. The research examines how circadian rhythms regulate synaptic function to modulate behavior with time of day, focusing on the molecular mechanisms by which the transcription factor BMAL1 and its phosphorylation at serine 42 orchestrate synaptic vesicle dynamics,...
- The National Institute of Neurological Disorders and Stroke awarded the Trustees of Boston University $170,132 under Project Grant F31NS145737 on December 1, 2025, to support research on the regulation of cerebral blood flow by intrinsic neuromodulation across wakefulness and sleep states. The award is made under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The research will examine neurovascular coupling through two coordinated aims....
- The National Institute of Neurological Disorders and Stroke awarded The Trustees of The University of Pennsylvania $243,750 on February 11, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds single-nucleus gene expression and chromatin accessibility profiling to identify and characterize neuronal heterogeneity in the murine hypothalamus during sleep and wake states. The research applies single-nucleus RNA sequencing...
- Federal Project Grant Award Summary Beth Israel Deaconess Medical Center, Inc. (BIDMC) was awarded $475,475 by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, effective July 1, 2025, through June 30, 2027. The research project investigates the pathophysiology of morning migraine—migraines characterized by symptom onset between 3–6 AM—with a focus on the relationship...
- The National Institute of Mental Health awarded The General Hospital Corporation (Massachusetts General Hospital) $765,876 on August 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to conduct advanced neuroimaging research on subcortical brain dynamics during human sleep. The recipient will use high-resolution 7-Tesla functional magnetic resonance imaging and simultaneous electroencephalography with a novel ultra-high-field compatible net to map circuit activity in the...
- The National Heart, Lung, and Blood Institute awarded Beth Israel Deaconess Medical Center, Inc. $1.738 million on August 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate serotonergic circuit mechanisms that enhance upper airway tone and respiration in patients receiving opioids and experiencing sleep-disordered breathing. The research identifies how brain serotonergic cell subtypes can offset adverse respiratory effects of opioids without compromising...
The National Institute of Neurological Disorders and Stroke awarded Beth Israel Deaconess Medical Center $475,475 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate the role of neurotensin-expressing neurons in the lateral hypothalamus in narcolepsy with cataplexy pathophysiology. The research examines whether enhancing lateral hypothalamic neurotensin neuron activity mitigates sleepiness and cataplexy in mouse models of narcolepsy caused by orexin loss. Aim 1 characterizes activity dynamics of these neurons across spontaneous sleep-wake cycles, acute sleep deprivation, and emotional stimuli that trigger cataplexy in both normal and orexin-knockout mice. Aim 2 determines causality by selectively activating or inhibiting lateral hypothalamic neurotensin neurons using optogenetic and chemogenetic methods in narcoleptic mice to assess effects on sleep-wake behavior and cataplexy. The work will identify novel neuronal populations involved in symptom relief and reveal potential pharmacological targets for narcolepsy treatment. Work is performed in Boston, Massachusetts. The award period runs through August 31, 2028. The assistance type is a Project Grant.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $475.5k | 9/1/26 |