Project Grant R01HL178578
Award Date 8/1/26
Completion Date 5/31/28
Dollars Obligated $1.7M
Federal Agency
Federal Grant Program
Assistance Type
Project Grant
Place of Performance
Boston, MA 02215, USA
Similar Awards
- The National Heart, Lung, and Blood Institute awarded the University of California, San Diego $792,154 on August 1, 2026, under NHLBI's Cardiovascular Diseases Research program (CFDA 93.837) to conduct a five-year study examining mechanisms by which chronic opioid use contributes to sleep-disordered breathing and ventilatory instability. The research, led by Dr. Jeremy Ott, an associate professor in the Division of Pulmonary, Critical Care, and Sleep Medicine at UCSD, will determine how...
- The National Heart, Lung, and Blood Institute awarded Brigham & Women's Hospital Inc. $894,690 on July 3, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate the mechanisms of hypoglossal nerve stimulation (HGNS) failure in obstructive sleep apnea treatment. The research examines laterally directed pharyngeal collapse as the anatomical cause underlying HGNS therapy failure. Current HGNS screening relies on drug-induced sleep endoscopy (DISE), an invasive...
- The National Heart, Lung, and Blood Institute awarded Brigham & Women's Hospital Inc. $492,250 on July 15, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to conduct data-driven phenotyping of obstructive sleep apnea and sex-specific cardiovascular consequences. The research integrates high-dimensional physiological and clinical data from the Mass General Brigham Health System electronic health record cohort, which includes over 144,000 patients with structured records...
- SMILE (Sickle Cell Disease Microbiologic and Immunologic Links to Health) - Respiratory Control Research Project Grant Emory University received a $794,661 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), with an award date of September 19, 2025, and a completion date of June 30, 2030. This research initiative investigates how higher-order brain regions interact with brainstem circuits to produce...
- The National Institutes of Health Office of the Director awarded University of Massachusetts Medical School $479,385 on June 1, 2026, under the Trans-NIH Research Support program (CFDA 93.310) to investigate targeting platelet-derived growth factor receptor beta (PDGFR-beta) as a means to prevent opioid-induced respiratory depression and overdose deaths. The research combines behavioral pharmacology and neuroanatomical protein and mRNA expression mapping in the mouse brainstem to test the...
- The National Heart, Lung, and Blood Institute (NHLBI) awarded Boston Children's Hospital $171,600 on September 1, 2026, under CFDA 93.837 (Cardiovascular Diseases Research) to support career development and mentored research in pediatric obstructive sleep apnea diagnostics. The award funds the recipient investigator's training in three areas: predictive modeling and machine learning, advanced physiological signal analysis, and implementation science for translating research into clinical...
- The National Heart, Lung, and Blood Institute awarded The Trustees of the University of Pennsylvania $1.542 million on September 15, 2025, under the Cardiovascular Diseases Research program (CFDA 93.837) to improve understanding of sleep apnea pathogenesis using novel imaging techniques during sleep. The research combines drug-induced sleep endoscopy (DISE) with dynamic magnetic resonance imaging (MRI) to characterize upper airway anatomy and the mechanisms of airway collapse during sleep. The...
- Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded $106,474 to the Regents of the University of Michigan on September 1, 2025, under the Cardiovascular Diseases Research program (CFDA 93.837) to support a K99/R00 Pathway to Independence award focused on investigating the role of endogenous opioids in respiratory development. The research will deliver scientific findings on how opioid signaling influences the development and physiology of brainstem respiratory...
- The National Heart Lung and Blood Institute awarded Brigham & Women's Hospital $3.243748 million on September 23, 2025, under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate the role of ambient lighting in circadian misalignment within a chronic variable sleep deficiency paradigm and its impacts on sleep, cognition, and central oxidative stress. The research examines how irregular sleep schedules—common among U.S. adults accommodating social and work...
- This Project Grant from the National Institutes of Health National Institute on Drug Abuse, under the Drug Abuse and Addiction Research Programs (CFDA 93.279), provides $640,000 to Olfa Thera, Inc. to develop new therapeutics targeting the OLFR78/OR51E2 receptor pathway in the carotid body. The goal is to identify OLFR78/OR51E2 agonists that can strongly stimulate carotid body activity and ventilation to reverse opioid-induced respiratory depression, without the side effects of existing...