Project Grant R21NS145420
- The National Institute of Neurological Disorders and Stroke, an institute of the National Institutes of Health, awarded The Regents of the University of California, San Francisco $205,200 on August 15, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds research into the role of microglia in cortical interneuron development in genetic and environmental disruptions associated with autism spectrum disorder. The work...
- The National Institute of Mental Health awarded Cincinnati Children's Hospital Medical Center $723,817 on August 24, 2026, under the Mental Health Research Grants program (CFDA 93.242) to study fragile X syndrome–associated blood-brain barrier defects and hypervascularization using blood-brain barrier assembloid models derived from patient-induced pluripotent stem cells. The research develops and validates BBB assembloid models combining neural and vascular components from fragile X syndrome and...
- The National Institute of Neurological Disorders and Stroke awarded Cincinnati Children's Hospital Medical Center $445,500 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to conduct genetic dissection of the rasopathy gene NF1 and MAPK pathway activation in cortical cell fate. The research investigates mechanisms regulating early stages of gliogenesis from cortical progenitors using mouse models. Three specific...
- The National Institute of Neurological Disorders and Stroke awarded Miami University $539,920 on September 5, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate how TSC1 loss disrupts Purkinje neuron axon initial segment organization and cerebellar function in autism spectrum disorder. The research examines the cellular mechanisms by which TSC1 deletion in Purkinje neurons alters axon initial segment function and...
- The National Institute of Neurological Disorders and Stroke awarded the University of Virginia $490,593 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate the role of growth differentiation factor 11 (GDF11) in neurodevelopmental disorders. The research examines GDF11 as a molecular hub involved in abnormal brain function across multiple genetically distinct neurodevelopmental disorders. The first...
- The National Institute of Child Health and Human Development awarded the University of California, Davis $683,451 on September 1, 2026, to conduct longitudinal neuroimaging research on maternal autoantibody-related autism (MAR) as a biologically defined autism spectrum disorder subtype, under CFDA 93.865 (Child Health and Human Development Extramural Research). The recipient will investigate autism-related maternal autoantibodies and immune dysregulation by analyzing the Autism Phenome...
- The National Institute of Neurological Disorders and Stroke awarded Emory University $430,375 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate spinal motor circuit dysfunction in autism spectrum disorder. The project examines the neural mechanisms underlying early motor impairments in ASD using two complementary mouse models: prenatal valproic acid exposure (representing environmental and...
- Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded Cincinnati Children's Hospital Medical Center a $900,000 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) on September 18, 2025, with an ultimate completion date of August 31, 2030. This mechanistic and translational medicine research initiative addresses critical knowledge gaps in Fragile X Syndrome (FXS) by establishing...
- The National Institute of Neurological Disorders and Stroke awarded Cincinnati Children's Hospital Medical Center $1.614 million on September 11, 2025, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to conduct basic research on epileptogenesis mechanisms in mtoropathies and develop AAV-mediated gene therapy approaches for intractable epilepsy caused by mTOR pathway mutations. The research leverages newly developed mouse models of...
- The National Institute of Neurological Disorders and Stroke (NINDS), part of the Department of Health and Human Services National Institutes of Health, awarded $153,560 to the Broad Institute, Inc. (doing business as Broad Institute of MIT and Harvard) on December 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds research examining how excitatory neurons regulate interneuron fate, position, and survival during...
The National Institute of Neurological Disorders and Stroke, a component of the Department of Health and Human Services National Institutes of Health, awarded $445,500 to Cincinnati Children's Hospital Medical Center on July 25, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to conduct preclinical research on microRNA-mediated regulation of IL-17A-associated neurodevelopmental defects induced by maternal immune activation. The research explores novel treatment strategies to prevent or ameliorate neurodevelopmental phenotypes in mice caused by maternal immune activation—infections during early pregnancy associated with autism and other neurodevelopmental disorders. The study leverages microRNA-mediated silencing to manipulate IL-17A pathway activity and downstream signaling components rather than targeting a single molecule, addressing feedback mechanisms that complicate conventional IL-17A-focused treatment approaches. The work hypothesis is grounded in the observation that IL-17A-targeting microRNAs are altered in individuals with autism. Performance occurs in Cincinnati, Ohio, with a period of performance from July 25, 2026, through June 30, 2028. The award is a Project Grant (R21), an assistance type supporting high-risk, high-reward research in the early or exploratory stages of investigation.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $445.5k | 7/27/26 |