Project Grant R01NS150458
- The National Institute of Neurological Disorders and Stroke (NINDS), part of the Department of Health and Human Services National Institutes of Health, awarded $153,560 to the Broad Institute, Inc. (doing business as Broad Institute of MIT and Harvard) on December 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds research examining how excitatory neurons regulate interneuron fate, position, and survival during...
- The National Institute of Neurological Disorders and Stroke awarded the University of Massachusetts Medical School $167,500 on July 14, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to determine biochemical roles for DPF1, DPF3, and PHF10 subunits in mammalian BAF ATP-dependent chromatin remodeling complexes. The research addresses molecular functions of these proteins, which are associated with neurodevelopmental disorders...
- The National Institute of Neurological Disorders and Stroke (NINDS), part of the Department of Health and Human Services National Institutes of Health, awarded The Medical University of South Carolina $100,228 on December 16, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds research on complement-mediated mechanisms of injury and repair in germinal matrix hemorrhage, a leading neurological injury of prematurity....
- The National Institute of Neurological Disorders and Stroke awarded the University of Massachusetts Medical School $551,557 on August 15, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate nucleic acid sensing pathways in demyelinating disease. The funded research dissects the role of endosomal toll-like receptors (eTLRs) in neuroinflammation and demyelination, specifically examining how aberrant eTLR signaling in...
- The National Institute of Neurological Disorders and Stroke, part of the National Institutes of Health, awarded Trustees of Tufts College (doing business as Tufts University School of Medicine) $453,750 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The project will define the therapeutic potential of GSK3 inhibition in correcting molecular phenotypes of CTNNB1 syndrome patient-derived glutamatergic neurons....
- The National Institute of Neurological Disorders and Stroke awarded the University of Virginia $565,250 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate microglial mechanisms in status epilepticus recovery. The research tests two hypotheses on how microglia facilitate seizure termination and recovery from prolonged seizures. Aim 1 investigates the role of microglial P2RY12 receptor inhibition of...
- The National Institute of Neurological Disorders and Stroke, part of the Department of Health and Human Services National Institutes of Health, awarded $555,000 to Augusta University Research Institute, Inc. on May 7, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds development of a novel optogenetic assay to study intracellular transport defects in neurodevelopmental diseases. The research addresses how motor...
- Federal Project Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded $395,009 to the University of California, Davis on August 1, 2025, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The two-year project, extending through July 31, 2027, supports foundational research to develop antisense oligonucleotide (ASO) therapy for ADNP syndrome (Helsmoortel-van der Aa syndrome), a severe...
- The National Institute of Neurological Disorders and Stroke, part of the Department of Health and Human Services National Institutes of Health, awarded Wake Forest University $533,623 on September 3, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds research investigating mechanisms that protect neurons from glutamate excitotoxicity during metabolic stress. The research uses avian neurons, which naturally resist...
- The National Institute of Neurological Disorders and Stroke awarded the University of North Carolina at Chapel Hill $110,943 on September 3, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds research examining how network dysfunction drives motor control impairments across monogenic neurodevelopmental disorders—specifically Angelman syndrome, Duplication 15q, Pitt Hopkins syndrome, and Rett syndrome. The...
The National Institute of Neurological Disorders and Stroke awarded the University of Virginia $490,593 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate the role of growth differentiation factor 11 (GDF11) in neurodevelopmental disorders. The research examines GDF11 as a molecular hub involved in abnormal brain function across multiple genetically distinct neurodevelopmental disorders. The first aim tests whether correcting GDF11 postnatally improves behavioral deficits in preclinical models of MECP2 duplication syndrome, including evaluation of the FDA-approved GDF11 inhibitor luspatercept as a targeted therapy. The second aim uses novel mouse models to investigate the consequences of GDF11 deletion and overexpression on brain function to establish the safety window of GDF11 expression. The work addresses the gap in FDA-approved treatments for neurodevelopmental disorders that affect nearly 15 percent of U.S. children. The award runs from September 1, 2026, through May 31, 2031, with place of performance in Charlottesville, Virginia. The University of Virginia serves as the recipient organization.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $490.6k | 8/21/26 |