Project Grant R21NS145030
- Federal Grant Award Summary The University of Minnesota received a $226,139 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), effective July 1, 2025 through June 30, 2027. The primary deliverable is the development and characterization of a human cerebellar organoid model of Spinocerebellar Ataxia Type 1 (SCA1), a dominantly inherited...
- Federal Project Grant Award Summary The University of Utah received a $512,423 Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), effective August 1, 2025 through July 31, 2030. This award funds fundamental neuroscience research investigating the role of IGF2BP3 (Insulin-like Growth Factor 2 mRNA-Binding Protein 3) and related RNA-binding proteins in...
- Federal Project Grant Award Summary Duke University's Office of Research Administration received a $392,863 Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), effective August 1, 2025, through July 31, 2026. The award supports the development of therapeutics for Spinocerebellar Ataxia Type 48 (SCA48), a neurodegenerative disease caused by mutations...
- Federal Project Grant Award Summary The University of Utah received a $1,188,230 Project Grant award dated July 15, 2025, from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award supports a five-year research initiative extending through June 30, 2030, investigating the pathophysiology of neuroma formation following closed-mechanism peripheral nerve injuries....
- Federal Grant Award Summary The University of Texas Southwestern Medical Center received a $156,760 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award, effective May 1, 2026, through April 30, 2027, supports research investigating the catalytic potential of three rare disease-associated pseudokinases—SCYL1, SCYL2, and TBCK—which have...
- Federal Project Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded $460,643 to the Regents of the University of Michigan on August 1, 2025, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to support a five-year research initiative extending through July 31, 2030. This Project Grant funds fundamental research investigating peripheral neuropathy in spinocerebellar ataxia type 3 (SCA3), the...
- Federal Project Grant Award Summary The University of Utah's Office of Sponsored Projects has received a $1.22 million Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), effective August 1, 2025, with a completion date of May 31, 2030. This research initiative addresses therapy resistance in Hedgehog (HH) pathway-driven medulloblastoma, the most common...
- Federal Project Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded the University of Massachusetts Medical School a Project Grant of $137,828 on November 1, 2025, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). This three-year research initiative, concluding October 31, 2028, will deliver a comprehensive single-cell analysis of somatic mutation rates, mechanisms, and impacts in human ataxia...
- Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded The Johns Hopkins University a Project Grant totaling $388,646 (awarded June 16, 2026; completion date May 31, 2031) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The research project investigates the molecular mechanisms of delta-2 receptor (GluD2) dysfunction in neurological diseases, specifically examining how...
- Federal Project Grant Award Summary The University of Miami, through its Office of Research Administration within the School of Medicine, received a $368,695 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), effective June 1, 2026, through May 31, 2027. The award supports research aimed at identifying and developing small-molecule inhibitors...
The University of Utah received a $423,500 Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, awarded on June 17, 2026, with completion targeted for May 31, 2028. This award funds research to elucidate the pathogenic mechanisms of expanded ZFHX3 in Spinocerebellar Ataxia Type 4 (SCA4), a disabling neurodegenerative disease characterized by progressive cerebellar ataxia. The research addresses a critical gap in understanding SCA4, for which no disease-modifying treatments currently exist and no suitable animal models are available. The funded research will generate cerebellar organoids derived from patient-derived induced pluripotent stem cells (iPSCs) from five SCA4 patients and matched family controls to investigate Purkinje cell pathogenesis. Specific deliverables include characterization of Purkinje cell viability, neuronal intranuclear inclusion (NII) protein composition, and proteostasis pathway dysfunction through single-nucleus RNA sequencing, as well as identification of potential therapeutic targets via lentiviral knockdown studies. This organoid-based approach will enable rapid advancement of mechanistic understanding and support accelerated development of therapeutic strategies for SCA4 and related polyglycine neuroinclusion diseases.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $423.5k | 6/18/26 |