Project Grant R61NS138384
- This Project Grant award of $226,139.00 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program supports research to develop a human cerebellar organoid model of Spinocerebellar Ataxia Type 1 (SCA1). The goal is to use this model to better understand how the genetic mutation that causes SCA1 impacts the human cerebellum and identify potential therapeutic targets. The...
- This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $423,500.00 to investigate cerebellar nuclei dysfunction in Spinocerebellar Ataxia Type 1 (SCA1). The research aims to determine how the cerebellar nuclei function is altered throughout SCA1 progression, how mutant ataxin-1 impacts the cerebellar nuclei, and how changes...
- This Project Grant award of $460,643.00 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program will support research to deeply understand spinocerebellar ataxia type 3 (SCA3), particularly its impact on the peripheral nervous system and connection to peripheral neuropathy. The research employs SCA3 mouse models to analyze the onset and progression of peripheral...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $128,343 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to the Regents of the University of Michigan to conduct research on "Elucidating the Contribution of Lipid Dysregulation to Impaired Oligodendrocyte Maturation and Myelination in Spinocerebellar Ataxia Type 3." The research aims to understand the mechanisms underlying impaired...
- This federal Project Grant award of $195,889 was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The award will fund research at Duke University to investigate the role of human-specific non-coding sequences within introns in regulating RNA splicing during cortical development and their relationship to neurological diseases like autism. Specifically, the...
- This $438,365 Project Grant awarded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research to investigate the role of the CD38 protein and its potential as a therapeutic target for Spinal and Bulbar Muscular Atrophy (SBMA). The research aims to use stem cell technology and CRISPR-corrected isogenic controls to examine metabolic alterations in SBMA patient-derived...
- This $438,342 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, aims to study the fundamental mechanisms by which ubiquitin ligases recognize and ubiquitinate substrates within protein complexes. The research focuses on understanding the role of the anaphase-promoting complex (APC) in regulating the composition of neuronal...
- This Cooperative Agreement award of $1,225,804, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will support a Phase 1 clinical trial to assess the safety and preliminary efficacy of bilateral cerebellar deep brain stimulation (DBS) in individuals with spinocerebellar ataxia (SCA) types 1 and 3. The study aims to understand the physiology of the deep...
- This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) is supporting research to investigate the role of the KIF1C motor protein in RNA transport and localization within neurons. The $430,375 award to Emory University will fund the development of a human neuronal disease model using CRISPR gene editing to study how KIF1C mutations impact the binding of...
- This $147,486 Project Grant awarded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program will support research to gain deeper insight into the pathophysiology of SCN3A-related neurodevelopmental disorder (SCN3A-NDD) and advance the development of effective therapeutic interventions. The research will utilize a novel mouse model of SCN3A-NDD to: 1) evaluate the...
This $392,863 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) will support research at Duke University to develop therapeutics for Spinocerebellar Ataxia Type 48 (SCA48), a rare genetic neurodegenerative disorder. The researchers will optimize and miniaturize assays to screen for small molecules that can restore the proper folding and function to the tetratricopeptide repeat domain of the CHIP protein, which is mutated in SCA48. Promising compounds will then be evaluated in cell culture models of SCA48 to determine if they can reverse the disease phenotypes. This work aims to identify potential therapeutic small molecules for this rare neurological condition.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 8/12/25 | ||
| Not listed | $392.9k | 7/31/25 |