Project Grant R01NS140063
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $128,343 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to the Regents of the University of Michigan to conduct research on "Elucidating the Contribution of Lipid Dysregulation to Impaired Oligodendrocyte Maturation and Myelination in Spinocerebellar Ataxia Type 3." The research aims to understand the mechanisms underlying impaired...
- This Project Grant award of $226,139.00 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program supports research to develop a human cerebellar organoid model of Spinocerebellar Ataxia Type 1 (SCA1). The goal is to use this model to better understand how the genetic mutation that causes SCA1 impacts the human cerebellum and identify potential therapeutic targets. The...
- This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $423,500.00 to investigate cerebellar nuclei dysfunction in Spinocerebellar Ataxia Type 1 (SCA1). The research aims to determine how the cerebellar nuclei function is altered throughout SCA1 progression, how mutant ataxin-1 impacts the cerebellar nuclei, and how changes...
- This $392,863 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) will support research at Duke University to develop therapeutics for Spinocerebellar Ataxia Type 48 (SCA48), a rare genetic neurodegenerative disorder. The researchers will optimize and miniaturize assays to screen for small molecules that can restore the proper folding and...
- This Project Grant award of $409,887.00 from the National Institute of Neurological Disorders and Stroke (NINDS) Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) will support research to investigate the mechanisms leading to small fiber neuropathy and loss of epidermal nerve fibers. The research aims to explore whether epidermal axons comprise a surveillance network that responds to threats on body surfaces, leading to nerve fiber density loss. Key areas...
- This Project Grant award of $129,717 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program supports research to investigate the role of neutrophils in the pathology of amyotrophic lateral sclerosis (ALS). The research, conducted by the Regents of the University of Michigan, aims to identify neutrophil subpopulations and mechanisms associated with ALS progression and...
- This federal Project Grant award of $168,321 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) will support research to investigate mechanisms of NPC1 protein homeostasis in human neurons. The research aims to determine the effectors mediating the folding, trafficking, and degradation of the NPC1 protein, which is mutated in Niemann-Pick disease type C, a rare lysosomal...
- This $438,365 Project Grant awarded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research to investigate the role of the CD38 protein and its potential as a therapeutic target for Spinal and Bulbar Muscular Atrophy (SBMA). The research aims to use stem cell technology and CRISPR-corrected isogenic controls to examine metabolic alterations in SBMA patient-derived...
- This $147,486 Project Grant awarded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program will support research to gain deeper insight into the pathophysiology of SCN3A-related neurodevelopmental disorder (SCN3A-NDD) and advance the development of effective therapeutic interventions. The research will utilize a novel mouse model of SCN3A-NDD to: 1) evaluate the...
- This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, is focused on developing a novel drug candidate to treat demyelinating neuropathies. The $352,073 award will support rigorous in vivo testing of the experimental ABCA1 agonist drug, CS6253, in validated mouse models of hereditary peripheral nerve disorders characterized by impaired...
This Project Grant award of $460,643.00 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program will support research to deeply understand spinocerebellar ataxia type 3 (SCA3), particularly its impact on the peripheral nervous system and connection to peripheral neuropathy. The research employs SCA3 mouse models to analyze the onset and progression of peripheral neuropathy through functional, histological, and transcriptional studies. The goal is to illuminate a cell-type specific mechanistic understanding of SCA3 peripheral neuropathy, which could have implications for therapeutic interventions in this and other multisystem neurodegenerative disorders. The award will fund this research project from August 1, 2025 through July 31, 2030 at the University of Michigan.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $460.6k | 7/24/25 |