Project Grant R21NS143024
- Federal Project Grant Award Summary Massachusetts Institute of Technology (MIT) received a $651,069 Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), awarded May 2, 2026, with completion targeted for April 30, 2031. The grant funds research to advance spatially multiplexed imaging technology for visualizing complex cellular signaling networks in...
- Federal Project Grant Award Summary Award Overview The National Institute of Neurological Disorders and Stroke (NINDS) awarded $578,701 to the University of California, Los Angeles (UCLA) through its Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) on June 16, 2025. The project, titled "Kilohertz 3D Voltage Imaging Using Near-Infrared Confocal Squeezed Light Field Microscopy," extends through May 31, 2030. Research Objectives and...
- Federal Project Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded UC Berkeley a Project Grant totaling $228,045 on February 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds fundamental neuroscience research spanning the grant period through January 31, 2028. The research focuses on developing ultrafast wireless voltage imaging technology using event-based cameras...
- Federal Project Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded The Ohio State University a $433,125 Project Grant effective August 1, 2025, through July 31, 2027, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). This research grant funds a comprehensive investigation into the transcriptional regulations governing cell-type-specific terminal differentiation of cortical interneurons,...
- Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded The Ohio State University a $540,322 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) effective August 1, 2025, through July 31, 2027. This award funds research investigating the role of three-dimensional (3D) chromatin architecture in axonal regeneration following peripheral nerve injury. The project addresses the...
- Federal Project Grant Award Summary Baylor College of Medicine received a $621,065 Project Grant from the National Institute of Neurological Disorders and Stroke under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), effective August 1, 2025, through July 31, 2030. The grant supports the development of advanced genetically encoded voltage indicators (GEVIs) optimized for two-photon resonant scanning microscopy applications. The primary...
- This Project Grant award, valued at $481,250.00 and provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, aims to develop a synthetic biological system to manipulate subcellular RNAs and proteins in growth cones or synapses of subtype- and context-specific neurons. The goal is to enable unique forms of subcellular functional investigation in subtype- and...
- Federal Project Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded The Ohio State University a Project Grant totaling $630,925 on May 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The five-year award, with completion scheduled for April 30, 2031, funds research investigating circadian clock physiology in cortico-limbic brain circuits and its relationship to complex behavioral...
- Federal Project Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded UCLA a Project Grant totaling $551,250 on June 1, 2025, under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The research focuses on understanding the molecular basis of synaptic specificity in the Drosophila melanogaster visual system. The project will investigate how neurons form precise synaptic connections through cell...
- Federal Project Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded J. David Gladstone Institutes a Project Grant of $1,375,478 under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), effective September 1, 2025, through August 31, 2033. This eight-year award supports multidisciplinary research investigating neurovascular dysfunction and its role in neurodegeneration, central nervous system (CNS)...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded The Ohio State University a $433,125 Project Grant effective May 1, 2026, through April 30, 2028, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). This award supports the development and optimization of a three-dimensional Total Internal Reflection Fluorescence Structured Illumination Microscope (3D TIRF-SIM), an advanced imaging technology designed to visualize synaptic vesicle exocytosis and endocytosis coupling at the nanoscale in living neurons. The research addresses a critical gap in neuroscience by enabling unprecedented spatial and temporal resolution imaging of these fundamental neuronal processes. The project deliverables encompass two primary objectives: iterative optimization of 3D TIRF-SIM experimental parameters using in vitro and in vivo imaging conditions to maximize resolution capabilities, and evaluation of the optimized technology's performance for high-resolution reconstruction of clathrin-coated structures in cultured cells and Drosophila melanogaster embryo tissues. By integrating super-resolution imaging with evanescent field nanometry, this innovation will advance understanding of neuronal communication mechanisms and provide researchers with a transformative tool for studying endocytosis and synaptic vesicle dynamics at unprecedented detail.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $433.1k | 4/27/26 |