This $638,454 Project Grant from the National Science Foundation's Biological Sciences program (CFDA 47.074) will fund research at Dartmouth College to define the functions of an essential, conserved mitochondrial protein that links the organelle's matrix to the cytoplasm. Over three years, the researchers will investigate how specific mitochondrial components integrate mitochondrial function within plant cells, focusing on the roles of ATAD3 proteins that span the inner and outer...
This Project Grant award, valued at $412,525.00 and issued by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research focused on the molecular mechanisms that regulate ADAR target recognition and RNA editing. The award will fund an integrated research approach using human cell lines and the model organism Caenorhabditis elegans to investigate how ADAR binding to target RNAs is influenced by...
This federal Project Grant award, with ID K08NS138707, was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The grant totaling $230,580 supports research to unravel the role of ATP synthase dimerization in energy regulation and adaptation to metabolic stress, with the ultimate goal of developing novel therapeutic approaches for mitochondrial disorders...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under CFDA Program 93.853 "Extramural Research Programs in the Neurosciences and Neurological Disorders", provides $484,125.00 to Trustees of Dartmouth College to conduct research on "Mitochondrial Dynamics Underlying Oligodendrocyte Generation". The research aims to determine how disruptions and alterations in mitochondrial dynamics impact oligodendrocyte precursor cell fate...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $793,777 to the J. David Gladstone Institutes, a non-profit biomedical research organization in San Francisco, CA, to conduct a 5-year study on the impact of mitochondrial genome architecture on the accumulation of somatic mitochondrial DNA mutations associated with cellular aging and age-related diseases. The research will utilize innovative long-read sequencing approaches to quantify...
This $578,440 Project Grant from the National Science Foundation's Biological Sciences program (CFDA 47.074) will fund research into defining the functions of an essential, conserved mitochondrial protein in plants. Over three years, the award supports collaborative investigations at San Diego State University into how specific mitochondrial components integrate mitochondrial function with the rest of the plant cell. Researchers will study ATPase Family AAA Domain-Containing Protein 3 (ATAD3)...
This $3,087,416 Project Grant awarded by the National Institute on Aging (CFDA 93.866 - Aging Research) to the Scripps Research Institute in La Jolla, CA aims to elucidate the mechanism by which the DELE1 protein activates the HRI kinase to transduce mitochondrial stress signals to the Integrated Stress Response (ISR) pathway. The research will use a range of structural, biochemical, and cellular studies to understand how DELE1 oligomerization, cleavage, and binding to HRI and eIF2A regulate ISR...
This Project Grant award of $638,682 from the National Institute on Aging (NIA), under the Aging Research program (CFDA 93.866), supports research to investigate the role of liquid-liquid phase separation (LLPS) of the TDP-43 protein and its interactions with mitochondria in neurodegenerative diseases. The research aims to systematically examine how LLPS regulates TDP-43 localization to mitochondria, and how this contributes to TDP-43-induced mitochondrial dysfunction and neuronal loss, using...
This Project Grant award for $466,125, provided by the National Institute on Aging (CFDA 93.866 - Aging Research), supports research to analyze the effects of Alzheimer's disease on subcellular transcriptome dynamics and mitonuclear coordination in neuronal soma and projections. The research, conducted by Harvard Medical School, will use a novel technique called Subcellular Timelapse-Seq (STL-Seq) to simultaneously quantify the kinetic rates of transcription, nuclear export, ribosome...
This $195,570 federal Project Grant award was made by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The award supports research by The Regents of the University of California, San Francisco (UCSF) to investigate the role of the molecular co-chaperone DNAJC7 in preventing the aggregation of misfolded proteins associated with neurodegenerative diseases such as...