This Project Grant award for $466,125, provided by the National Institute on Aging (CFDA 93.866 - Aging Research), supports research to analyze the effects of Alzheimer's disease on subcellular transcriptome dynamics and mitonuclear coordination in neuronal soma and projections. The research, conducted by Harvard Medical School, will use a novel technique called Subcellular Timelapse-Seq (STL-Seq) to simultaneously quantify the kinetic rates of transcription, nuclear export, ribosome...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to elucidate the molecular mechanisms underlying the neurodegenerative function of a subset of microglia (the brain's immune cells) in Alzheimer's disease (AD). The $442,357 award, effective December 15, 2024 through November 30, 2029, supports research by the Research Foundation of the City University of New York's Advanced Science Research Center to investigate how cellular stress signaling,...
This $1,737,000 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports the development of innovative single-cell genomics technologies for joint analysis of regulatory dynamics and transcriptional states. Key objectives include: Developing multiomics tools to measure rates of epigenomic changes (DNA methylation, demethylation, oxidative damage, DNA repair) and relate these to...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will provide $793,777 to the J. David Gladstone Institutes, a non-profit biomedical research organization in San Francisco, CA, to study the impact of mitochondrial genome architecture on the accumulation of somatic mitochondrial DNA (mtDNA) mutations over an individual's lifetime. The research aims to understand how mtDNA compaction influences mutation rates and mitochondrial health, with potential...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $399,766 to the University of Kansas Center for Research Inc. from January 1, 2025 to December 31, 2026. The project aims to understand the dynamics between mitochondrial and nuclear genome variation, and how this impacts mitochondrial dysfunction and associated diseases like neuromuscular disorders, cancers, and metabolic diseases. The research will leverage a novel animal model, the threespine...
This Project Grant award for $866,764 from the National Institute on Aging's Aging Research Program (CFDA 93.866) supports an interdisciplinary research study at the University of California, San Francisco (UCSF) to investigate human-specific vulnerabilities and compensatory adaptations of midbrain dopaminergic neurons in response to age-related stressors. The project aims to leverage stem cell-derived organoids, primary tissue samples, machine learning, and CRISPR techniques to directly measure...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research into the cell autonomous and cell non-autonomous roles of mitochondrial proline catabolism in health and longevity. The $126,042 award to the University of Southern California, effective February 1, 2025 through July 31, 2025, will employ innovative techniques including CRISPR/Cas9 genetic editing, single-cell RNA sequencing, and mitochondrial assessments to comprehensively characterize...
This Project Grant award of $1,156,508 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research to investigate the role of mitochondrial metabolism in regulating species-specific developmental rates. The project aims to leverage an in vitro system that recapitulates the difference in developmental rate between mouse and human cells to understand why basal metabolic rates are elevated in mouse...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $1,216,094 in funding to the University of California, San Diego to investigate a novel mechanism of dysfunctional mitophagy (selective autophagy of mitochondria) and its role in brain ischemia-reperfusion injury. The objective is to determine if inactivation of the...
The Scintillon Institute, a non-profit biomedical research organization, received a $529,650 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to investigate NAD(P)H quinone oxidoreductase 1 (NQO1)-mediated bypass of the mitochondrial electron transport chain. The research aims to identify endogenous metabolites interconverted by NQO1 and characterize the bioenergetics of this alternative electron transfer mechanism, with the goal of developing therapeutic...
This Project Grant award of $3,087,416.00 from the National Institute on Aging (NIA), under the Aging Research program (CFDA 93.866), supports research to elucidate the mechanism by which the DELE1 protein activates the HRI kinase to relay mitochondrial stress to the Integrated Stress Response (ISR) pathway. The research aims to provide a comprehensive, mechanistic description of the key interactions between DELE1, HRI, and eIF2A that transduce mitochondrial stress to ISR activation. The award supports structural, biochemical, and cellular studies to understand how DELE1 oligomerization leads to HRI activation, the role of DELE1 cleavage in this process, and the structural details of eIF2A recruitment and activation by HRI. This work could enable the development of targeted therapeutic interventions to modulate the DELE1-HRI-eIF2A pathway for mitochondrial disease treatment while preserving the cell's ability to respond to other stresses. The award period runs from August 15, 2024 to April 30, 2029 and is being conducted by the Scripps Research Institute in La Jolla, CA.