Project Grant R21NS142767
- The National Institute of Neurological Disorders and Stroke, part of the Department of Health and Human Services National Institutes of Health, awarded $544,568 to Cleveland Clinic Lerner College of Medicine of Case Western Reserve University on February 11, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate the pathogenesis of permanent neurological disability in multiple sclerosis. The research identifies cellular...
- The National Institute of Neurological Disorders and Stroke awarded Cleveland Clinic Lerner College of Medicine of Case Western Reserve University $877,250 on May 6, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate aberrant M6A methylation correlating with hippocampal pathology in multiple sclerosis. The research examines how demyelination alters N6-methyladenosine (M6A) methylation patterns in gene transcripts...
- The National Institute of Neurological Disorders and Stroke, part of the Department of Health and Human Services, awarded The Ohio State University $424,333 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to develop a bioengineered blood-brain barrier-on-a-chip microphysiological system for improved drug screening in primary brain tumors. The project addresses the challenge of modeling glioblastoma cellular...
- The National Institute of Neurological Disorders and Stroke, a component of the Department of Health and Human Services National Institutes of Health, awarded the University of Cincinnati $654,628 on March 6, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to characterize the peripheral and immune-cell proteome in intracerebral hemorrhage patients and identify biomarkers and mechanisms associated with vascular cognitive...
- Federal Grant Award Summary Cleveland Clinic Lerner College of Medicine of Case Western Reserve University received a $442,750 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), effective August 1, 2025 through July 31, 2027. The award supports research investigating extrachromosomal DNA (ecDNA) in human glioblastoma, with focus on...
- The National Institute of Neurological Disorders and Stroke (NINDS), part of the Department of Health and Human Services National Institutes of Health, awarded The Medical University of South Carolina $100,228 on December 16, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds research on complement-mediated mechanisms of injury and repair in germinal matrix hemorrhage, a leading neurological injury of prematurity....
- The National Institute of Neurological Disorders and Stroke awarded The Ohio State University $433,125 on May 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to develop and optimize a three-dimensional total internal reflection fluorescence structured illumination microscope (3D TIRF-SIM) for investigating synaptic vesicle exo-endocytosis coupling in living cells. The research addresses a critical gap in neuroscience by...
- The National Institute of Neurological Disorders and Stroke awarded Case Western Reserve University $109,412 on January 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to evaluate the protein homeostasis of N-methyl-D-aspartate receptors containing pathogenic GluN2B subunits. The research elucidates the proteostasis network regulating NMDA receptor folding, assembly, trafficking, and degradation, with emphasis on how...
- The National Institute of Neurological Disorders and Stroke, part of the Department of Health and Human Services National Institutes of Health, awarded Yale University $667,613 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds research examining ferroptosis—iron-induced programmed cell death—in erythrocytes within intracerebral hemorrhage hematomas. The project investigates how heme induces...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded The Regents of the University of California, San Francisco $128,139 on September 23, 2025, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds research to develop a multi-modal transcriptomic atlas of normal and diseased cerebral vasculature, with focus on mural cell biology in brain arteriovenous malformations (BAVMs). The research consists of two...
The National Institute of Neurological Disorders and Stroke awarded $235,500 to Cleveland Clinic Lerner College of Medicine of Case Western Reserve University on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to support single-cell morphological dissection of brain endothelial cells. The award funds research investigating cerebrovascular integrity at the single-cell level, with focus on endothelial cell morphometrics across different capillary subtypes. The project employs zebrafish as an animal model with an EC-specific photoconversion system to enable single-cell labeling and direct comparison of morphological characteristics between blood-brain barrier and fenestrated brain endothelial cell subtypes in vivo during development, homeostasis, and pathology. The research aims to establish linkages between morphological traits, permeability parameters, and transcriptomic profiles to advance understanding of neurological disorders and improve early detection and treatment approaches. Performance occurs in Cleveland, Ohio. The award period runs from September 1, 2026, through August 31, 2028. This is a Project Grant, a standard NIH research assistance mechanism.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $235.5k | 8/27/26 |