Project Grant R21NS144792
- This $1,449,000 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) supports research to study the fundamental regulation of extrachromosomal DNA (ecDNA) in cancer genomes. The project aims to develop new live-cell chromatin labeling strategies and integrate advanced imaging, synthetic genome engineering, and optical/genetic perturbation to systematically investigate how ecDNA orchestrates massive...
- This $638,697 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program supports research by the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University (CCLCM) to investigate the role of the SMARCA5 protein in the development and progression of glioblastoma, an aggressive type of brain cancer. The goal of the research is...
- This Project Grant award from the National Cancer Institute (CFDA 93.398 - Cancer Research Manpower program) provides $144,981 to the University of California, San Diego (UC San Diego) to characterize the role of extrachromosomal DNA (ecDNA) in shaping the heterogeneity and plasticity of glioblastoma (GBM) cellular states. The award period runs from September 3, 2025 to August 31, 2027. The project aims to determine how ecDNA, which are large circular DNA elements harboring oncogenes,...
- This federal Project Grant award of $131,360 from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, is funding research at the University of New Haven to characterize the long non-coding RNA GIHCG and assess its potential as a therapeutic target for glioblastoma, the most aggressive form of brain cancer. The 4-year project aims to use CRISPR/Cas9 gene editing to...
- This $452,375 federal Project Grant awarded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) supports research investigating the role of nuclear mechano-transduction in regulating gene expression and shaping the spatial landscape in glioblastoma (GBM). The 2-year research project, running from August 2025 to July 2027, will be conducted by The Trustees of Columbia...
- This Project Grant award of $652,751 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research to engineer antibody drug conjugates (ADCs) designed to enhance the therapeutic window for treating glioblastoma (GBM) and other central nervous system cancers. The research, conducted by the Mayo Clinic, aims to leverage key findings from prior preclinical studies...
- The National Cancer Institute (CFDA 93.393 - Cancer Cause and Prevention Research) awarded a $3,201,530 Project Grant to the Sloan-Kettering Institute for Cancer Research to investigate the mechanisms underlying extrachromosomal DNA (ecDNA) segregation and repair in cancer. The key focus areas include: Exploring how the circular topology of ecDNA affects its function and maintenance, specifically examining the RNA-dependent physical tethering of ecDNA to mitotic chromosomes that facilitates...
- This Project Grant award of $687,279 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research to uncover the effects of standard-of-care therapy on immune and neoplastic cell population dynamics in pre-clinical mouse models of glioblastoma (GBM) and analysis of human GBM samples. The goal is to identify tumor microenvironment areas of therapeutic...
- This federal Project Grant award of $460,940 from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research conducted by the University of Texas MD Anderson Cancer Center to investigate how genetic risk factors for glioma, a type of brain cancer, impact neurodevelopmental processes and potentially promote tumor formation. The research leverages human...
- This $245,434 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research at the University of Pennsylvania to map the neural circuit connectivity of human high-grade glioma brain tumors in a mouse model. The goal is to define the whole-brain inputs onto glioblastoma cells using monosynaptic tracing techniques to understand how neuronal...
This $442,750 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program supports research to induce and image extrachromosomal DNA (ecDNA) in human glioblastoma cells. The primary goals are to determine if EGFR ecDNA causally fuels glioblastoma tumorigenesis, elucidate how centromere-less ecDNA propagates to daughter cells during mitosis, and reveal the molecular mechanisms by which ecDNA promotes glioblastoma cell heterogeneity. This 2-year project will utilize a clinically relevant glioblastoma model system and optimize ecDNA labeling and imaging techniques to address critical knowledge gaps in understanding ecDNA's role in driving glioblastoma progression and therapeutic resistance. The award recipient is the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, a prominent academic medical institution with extensive federal research grant experience.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $442.8k | 7/25/25 |