The Project Grant award of $492,749 from the National Institute of Neurological Disorders and Stroke (NINDS) under CFDA 93.853 "Extramural Research Programs in the Neurosciences and Neurological Disorders" will fund the development and validation of a novel magnetic resonance imaging (MRI) technique called Ratiometric Dual (RDUAL) pH-weighted MRI. This innovative approach aims to accurately map tissue acidosis in the ischemic penumbra and core during acute ischemic stroke, enabling...
This $596,783 Project Grant awarded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program supports research to harness mitochondria transfer pathways as a potential therapeutic strategy for treating Leigh syndrome, a fatal inherited mitochondrial disease. The research aims to determine how administering exogenous mitochondria and bone marrow...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $1,208,638 to Emory University to investigate the therapeutic potential of targeting NADH-reductive stress in mitochondrial diseases. The key objectives are to: (A) assess how an engineered enzyme called LOXCAT impacts metabolism and mitochondrial function in primary cell...
This $497,196 Project Grant awarded by the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, supports the development of a novel magnetic resonance spectroscopic imaging (MRSI) pulse sequence. The objective is to simultaneously map both upfield (UF) and downfield (DF) proton signals throughout the human brain at 3T, which may provide valuable metabolic...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $419,038 Project Grant (CFDA 93.853 - Extramural Research Programs in the Neurosciences and Neurological Disorders) to the University of North Dakota to develop a miniature selective plane illumination fluorescence microscope for high-resolution volumetric imaging in freely behaving mice. The goal is to create a transformative machine learning-augmented miniature adaptive optics light-sheet microscopy platform to...
This $443,354 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to investigate metabolic dependencies and resistance mechanisms in pediatric diffuse midline glioma (DMG) brain tumors harboring the H3K27M mutation. The research aims to understand how targeting the hexosamine biosynthetic pathway, either alone or in...
The University of Pittsburgh was awarded a $215,896 Cooperative Agreement under the National Institute of Neurological Disorders and Stroke's (NINDS) Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program. The award, titled "N3-PREP (Neurology, Neurosurgery, & Neuropathology Pitt Research Education Program)", will establish a training program to develop the next generation of physician-neuroscientists. Key components include...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $606,548.00 to the University of Pittsburgh to develop a new brain recording technology called "mesoscopic electrophysiology." This innovative system will use a 3D grid of 1,920 intracranial electrodes to simultaneously record neural activity across an entire...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $499,286.59 to the University of Pittsburgh to conduct research on the role of the LRRK2 protein in Parkinson's disease pathogenesis. The research aims to elucidate how wild-type LRRK2 kinase activity is stimulated, its translocation to mitochondria under oxidative stress...
This $431,750 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, supports the development of an innovative Positron Emission Tomography (PET) molecular neuroimaging technique. The goal is to non-invasively and repeatedly image whole-brain neurocircuitry involved in complex behaviors and cognitive tasks in awake mammals. The...