This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the federal Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will fund the development of a miniaturized optical imaging device called a "synthetic mesoscope." The goal is to create a compact, high-resolution imaging system that can monitor neural activity across large areas of the brain in freely-behaving animals. The $526,366...
The University of Minnesota was awarded a $3,972,414 Project Grant from the National Institute of Neurological Disorders and Stroke within the Department of Health and Human Services to develop an electro-optical multiphoton microscope. The microscope will leverage advances in electro-optical beam deflection to enable random-access multiphoton interrogation of neurons and synapses with sub-microsecond access times. This will allow neuroscientists to collect the simultaneous recordings needed...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), part of the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853), provides funding to North Carolina State University (NC State) to develop an automated imaging and analysis platform for unbiased, high-resolution study of glial cell development in the mouse forebrain. The $538,523 award aims to optimize a pipeline for simultaneous detection and classification...
The National Institute of Biomedical Imaging and Bioengineering (NIBIB) awarded a $187,831 Project Grant (R21EB035306) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to the University of California, Davis. This grant will fund the development of a new miniature two-photon microscope that can simultaneously perform high-resolution calcium imaging and optogenetic stimulation of neural activity in freely-behaving mice. The...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, provides $399,077 to the University of California, Berkeley to optimize in vivo 2-photon imaging methods for studying sensory and cognitive signals in the somatosensory cortex of awake, behaving mice. The project aims to develop and validate advanced optical voltage imaging...
This $204,688 Project Grant awarded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program supports the development of a novel, cloud-based microscope system called "NEUROVU". The NEUROVU system is designed to enable continuous, real-time in vivo "neurosurveillance" of the interactions between seizure-induced neuronal hyperexcitability and brain tumor...
The National Institutes of Health National Institute of Neurological Disorders and Stroke awarded $1,852,675 under the 21st Century Cures Act - Brain Research through Advancing Innovative Neurotechnologies program (CFDA 93.372) to the University of California, Los Angeles from August 1, 2022 to July 31, 2025. The award will support the development of light field tomographic microscopy for kilohertz volumetric imaging of neuronal action potentials in awake behaving mice. Specifically, the...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a Project Grant of $606,548 to the University of Pittsburgh under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program. The purpose of this award is to develop a new recording modality called "mesoscopic electrophysiology" that combines the full-brain coverage and spatial resolution of fMRI with the temporal resolution of electrophysiology in...
The Johns Hopkins University was awarded a $2,008,605 Project Grant under the National Institute of Neurological Disorders and Stroke's 21st Century Cures Act - Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative (CFDA 93.372). The grant funding will support the development of an "Autonomous Rapidly Adaptive Multiphoton Microscope for Neural Recording and Stimulation." This adaptive multiphoton microscope system will leverage hybrid volumetric scanning,...
This Project Grant from the National Institutes of Health's National Institute of Neurological Disorders and Stroke will fund the development of advanced tools for genetically targeted all-optical electrophysiology in behaving mice. Specifically, the $4,381,836 award to President and Fellows of Harvard College, doing business as Harvard University, will support efforts to co-develop two-photon excitable genetically encoded voltage indicators and a new type of two-photon voltage-imaging...