The University of Pittsburgh has been awarded a Project Grant of $492,749 by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The goal of this 5-year project is to develop a novel non-invasive magnetic resonance imaging (MRI) technique called Ratiometric Dual Contrast (rDUAL) pH-weighted MRI to better assess tissue acidosis in acute ischemic stroke patients. The rDUAL approach aims to more accurately map the penumbra (at-risk tissue) and predict the severity of reperfusion injuries compared to current diffusion and perfusion-based MRI methods. Ultimately, this metabolic imaging tool is intended to help guide personalized treatment decisions for recanalization therapies and neuroprotective drugs in acute stroke.
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