Project Grant R21NS140846
- Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded the University of Cincinnati a $654,628 Project Grant effective March 6, 2026, through February 28, 2031, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). This award supports research investigating proteomics and cognitive decline following intracerebral hemorrhage (ICH), a stroke subtype with the highest dementia risk among stroke...
- Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded the Regents of the University of Michigan a $633,146 Project Grant effective August 4, 2025, through July 31, 2030, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). This research initiative addresses the identification of modifiable factors associated with vascular cognitive impairment and dementia (VCID) occurring after stroke, a...
- Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded UC San Diego a Project Grant of $438,625 on August 7, 2025, under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The award funds research investigating a novel neuronal pro-survival mechanism called "actinification," a reorganization of the neuronal actin cytoskeleton triggered by ischemic brain injury. The research...
- Federal Project Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded J. David Gladstone Institutes a Project Grant of $1,375,478 under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), effective September 1, 2025, through August 31, 2033. This eight-year award supports multidisciplinary research investigating neurovascular dysfunction and its role in neurodegeneration, central nervous system (CNS)...
- Federal Project Grant Award Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded University of California, Los Angeles $180,943.00 under the Oral Diseases and Disorders Research program (CFDA 93.121) on June 13, 2025, for research addressing therapeutic targeting of apical periodontal T-cells in chronic oral inflammation. The research initiative, which extends through May 31, 2030, investigates the pathogenic mechanisms underlying apical periodontitis—a chronic...
- Federal Project Grant Award Summary Indiana University Indianapolis received a $165,512 Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), awarded June 1, 2026, with completion targeted for October 8, 2029. The funded research investigates platelet-mediated mechanisms contributing to vascular contributions to cognitive impairment and dementia (VCID) in...
- Federal Project Grant Award Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded the University of Illinois a $320,660 Project Grant on April 6, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to conduct basic research on the immunoregulatory function of dendritic cell subsets in periodontal disease. The 24-month research initiative, concluding April 5, 2028, will investigate how three dendritic cell subsets—myeloid dendritic cells...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded the University of Illinois a $2.55 million Project Grant under the Aging Research program (CFDA 93.866) on August 11, 2025, with a completion date of July 31, 2029. This research project investigates the mechanisms by which SARS-CoV-2 infection increases the risk of vascular contributions to cognitive impairment and dementia (VCID). The research will examine how COVID-19 weakens the blood-brain barrier (BBB) through...
- Federal Project Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded The Leland Stanford Junior University a Project Grant totaling $125,685 on August 9, 2025, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award supports research and development of a bioactive material intervention to address post-stroke dementia, a significant complication affecting approximately 7 million stroke...
- Federal Project Grant Award Summary Indiana University Indianapolis received a $225,144 Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), awarded December 5, 2025, with completion targeted for May 15, 2027. The grant funds investigative research examining neutrophil activity and contributions to cognitive impairment in a comorbid disease model...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a Project Grant totaling $431,750 to the University of California, Irvine (UCI), effective June 1, 2026 through May 31, 2028, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). This research project investigates the relationship between periodontitis and cognitive decline by examining vascular contributions to cognitive impairment and dementia (VCID) caused by cerebral microbleeds. The research will utilize novel animal models to identify specific mechanisms linking periodontitis—an emerging dementia and stroke risk factor—to cerebral microhemorrhage formation, particularly in the context of hypertension and aging. The research deliverables encompass two primary objectives: (1) determining the effects of periodontitis on cerebral microhemorrhage development, size, and source vessels in hypertensive and aging mouse models, and establishing whether CXCR3 antagonists can inhibit periodontitis-enhanced microhemorrhage formation and associated cognitive decline; and (2) elucidating the role of microglial activation in mediating periodontitis-induced microhemorrhage formation. The multidisciplinary research team brings expertise in stroke neurology, vascular neurobiology, brain aging, bioengineering, brain imaging, and biostatistics to address the pathophysiologic mechanisms underlying hemorrhagic microvascular disease in the aging brain.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $431.8k | 5/29/26 |