This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $525,436 to the Icahn School of Medicine at Mount Sinai to conduct research on the structural pharmacology of GIRK channel disease mutants. The key objectives are to elucidate the molecular mechanisms underlying the loss of potassium selectivity and G protein-independent...
This Project Grant award, valued at $1,330,586.00, was provided by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242). The funding supports research to investigate how changes in cerebrospinal fluid (CSF) potassium levels during brain development affect neural progenitor maintenance, neurogenesis, and brain physiology. The awardee, The Leland Stanford Junior University, will use explant manipulation and in vivo gene delivery techniques to...
This Project Grant award of $655,968 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) will fund research to unravel the genotype-phenotype connections of three gain-of-function variants of the KCNMA1-encoded BK potassium channel. The goal is to understand how these variants influence distinct molecular gating mechanisms, leading to differential alterations of neuronal...
This Project Grant award of $471,402 from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research at Yale University to investigate the role of the KV3.4 potassium channel and its interaction with the cell adhesion molecule protocadherin 9 (PCDH9) in neuronal development. The research aims to determine how the KV3.4/PCDH9 complex triggers the formation of...
This Project Grant award, with the federal grant ID R00GM146028, was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The award totals $501,985.34 and will fund research to elucidate the structural consequences of protein kinase C (PKC)-dependent phosphorylation of the KV7.2 ion channel subunit over a project period from August 12, 2024 to July 31, 2027. The research aims to provide a mechanistic...
This Project Grant award, totaling $101,668.00, was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program. The award supports research to investigate the role of the PANX1 ion channel in cortical development and its potential contribution to the pathogenesis of polymicrogyria, a malformation of the cerebral cortex. Key objectives include...
This $412,077 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research by Colorado State University to investigate the role of SLO2 potassium channels in olfactory adaptation. The key objectives are to genetically manipulate the expression of the SLO2 channel in the fruit fly model system, test for impacts on olfactory adaptation in vivo,...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will support research to investigate how mechanosensation at the choroid plexus contributes to intracranial pressure (ICP) regulation in health and disease. The $296,108 award to the Scripps Research Institute will fund experiments using electrophysiology, calcium imaging, and ICP...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $361,975 to support research focused on developing chemical strategies for imaging and manipulating astrocytes in the brain. The project aims to expand the capabilities of an astrocyte-targeting chemical tag to enable direct visualization and modulation of astrocyte...
This federal Project Grant award, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to better understand and potentially develop new treatments for neurological conditions such as pain and ischemic stroke. The $231,000 award, spanning from April 2025 to March 2027, will fund efforts at the University of Rochester to: 1) identify the binding...