Project Grant R21NS135729
- This federal Project Grant award of $364,448.00 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) focuses on investigating the neural functions of glycoprotein sialylation. The research aims to reveal sialylation-mediated mechanisms of glia-neuron coupling, elucidate the role of sialylation in promoting neuronal viability and resistance to oxidative stress, and characterize...
- This Project Grant award of $433,125.00 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research by The Ohio State University into the functional expression of the small conductance Ca2+-activated K+ channel, SK2, as a potassium channel that contributes to the passive potassium conductance in astrocytes. The project aims to correlate the SK2 channel gene...
- This Project Grant award of $671,775.00 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research to elucidate the molecular mechanisms and therapeutic potential of SLC4 bicarbonate transporters expressed in the brain. The project aims to combine structural studies, computational modeling, in silico drug discovery, and validation in cell-based and animal models to...
- This $132,377 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) will support research by the University of California, Los Angeles (UCLA) to identify the cells and circuits driving stimulus-independent activity throughout the developing Drosophila (fruit fly) brain. The research aims to understand how coordinated, spontaneous neural activity across...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $404,340 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to the University of Georgia Research Foundation, Inc. The project aims to develop a novel method using split fluorescent protein tags to map the localization of neurotransmitter receptors within neural circuits in the Drosophila model organism. This work will provide crucial new insights into the...
- This federal Project Grant award of $194,375 from the National Institute on Deafness and Other Communication Disorders (CFDA 93.173 - Research Related to Deafness and Communication Disorders) supports research to investigate the cellular and molecular basis for how insects, specifically fruit flies, detect and respond to high osmolality in food. The project aims to define the role of osmolality in modulating feeding behavior in fruit flies, and to identify the specific gustatory neurons and...
- This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, is providing $529,878 to Boston Children's Hospital from December 1, 2024 to November 30, 2029. The project aims to investigate the molecular mechanisms underlying the desensitization of dopamine receptors that occurs after goal-directed behaviors, such as mating in Drosophila. This...
- This federal Project Grant award of $426,938, provided by the National Institute on Deafness and Other Communication Disorders (NIDCD) under the Research Related to Deafness and Communication Disorders program (CFDA 93.173), will support research to investigate the structural basis for chemosensation by insect olfactory ionotropic receptors. The research will be conducted by The Johns Hopkins University, a leading federal research institution, from August 1, 2025 to July 31, 2027. The project...
- This federal Project Grant award of $525,436.00 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) will support research on the structural pharmacology of GIRK channel disease mutants. The research aims to elucidate the molecular mechanisms underlying the loss of potassium selectivity and constitutive activation of GIRK2 channels associated with Keppen-Lubinsky syndrome, a...
- This federal Project Grant award, ID R35NS137247, was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The award totaling $1,174,913.00 supports research to understand the fundamental mechanisms of homeostatic plasticity, a compensatory process that stabilizes neural function, and its potential links to neurodevelopmental disorders such as autism and...
This $412,077 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research by Colorado State University to investigate the role of SLO2 potassium channels in olfactory adaptation. The key objectives are to genetically manipulate the expression of the SLO2 channel in the fruit fly model system, test for impacts on olfactory adaptation in vivo, identify the specific cells and subcellular domains where SLO2 channels affect adaptation, and use electrophysiology to examine how SLO2 channels influence the excitability of these cells. This research aims to elucidate a novel mechanism by which the SLO2 channel, which is activated by the major depolarizing ion sodium, may act as an intrinsic hyperpolarizing mechanism to dampen excessive neuronal excitation and support sensory adaptation. The award provides funding for the 2-year project period from September 15, 2023 to August 31, 2025.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $412.1k | 9/14/23 |