Project Grant R21NS138705

Award Date 4/1/25
Completion Date 3/31/27
Dollars Obligated $231K
Federal Grant Program
93.853
Assistance Type
Project Grant
Place of Performance
New York, USA
Similar Awards
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), part of the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853), provides $885,128 to Duke University to conduct research on the structure, function, and pharmacology of sensory receptor ion channels in somatosensory neurons. The research aims to gain a molecular-level understanding of the design principles governing somatosensation and nociception,...
This Project Grant award for $158,512.00, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to characterize the role of orexinergic neurons in the lateral hypothalamus and their descending projections to the spinal cord in modulating chronic pain. The primary objectives are to use two-photon calcium imaging and chemogenetic activation...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) provides $213,284 to the University of Texas at Dallas to conduct research on resurgent currents in human dorsal root ganglia neurons. The key objectives are to: 1) characterize voltage-gated sodium channel expression and modulation in human nociceptors, 2) determine if human nociceptors exhibit...
This Project Grant award, valued at $597,999.00, was issued by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The funding supports research at the University of Pittsburgh focused on understanding the neuronal populations and central sensitization mechanisms underlying mechanical allodynia, a type of persistent pain, in the dorsal horn. Key objectives include...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $441,500 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to Duquesne University of the Holy Spirit. The purpose of this 3-year grant, beginning September 2023, is to utilize laboratory data and computational 3-D modeling to analyze the role of the central amygdala in neuropathic pain. Specifically, the project aims to build a proof-of-concept 3-D...
This federal Project Grant award of $675,107 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research to develop novel non-opioid, non-addictive analgesics for treating neuropathic pain. The award funds a collaborative research effort across five laboratories to design, synthesize, and evaluate a series of "dualsteric" cannabinoid receptor ligands...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, will provide $560,934 to the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University from April 1, 2025 to March 31, 2030. The award will support research to define the temporal patterns and characteristics of neural oscillations in the somatosensory...
The Project Grant award R61NS133704, totaling $1,846,202.00, was provided by the National Institute of Neurological Disorders and Stroke under the Drug Abuse and Addiction Research Programs (CFDA 93.279) to Duke University. The primary objective is to develop potent, selective, and peripherally-restricted antagonists of the adrenergic receptor beta-3 (ADRB3) for the treatment of chronic primary pain conditions affecting over 100 million people. This will involve: 1) developing novel ADRB3...
This federal Project Grant award, valued at $238,276, was provided by the National Institute of Neurological Disorders and Stroke under the Drug Abuse and Addiction Research Programs (CFDA 93.279). The funding supports research at the University of California, Irvine to investigate the role of the enzyme N-acylethanolamine acid amidase (NAAA) in the development of hyperalgesic priming, a model for studying the transition from acute to chronic pain. The project aims to identify the receptor...
This $246,750 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) will support research to investigate the role of the mesocortical glutamatergic pathway in the development and maintenance of chronic neuropathic pain. The research project aims to examine how changes in glutamatergic inputs from the ventral tegmental area (VTA) to the prefrontal cortex...

This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) will provide $231,000.00 to the University of Rochester to conduct research to overcome challenges in developing analgesic treatments targeting acid-sensing ion channels (ASICs). The key objectives are to: 1) identify the binding site for the ASIC3 inhibitor APETx2 using computational docking and experimental methods, and 2) generate and test novel bivalent toxins that can modulate heteromeric ASIC complexes, which may lead to new peripheral pain management approaches. The award term is from April 1, 2025 to March 31, 2027.

Generated 4/8/25, 3:44 AM