The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $426,250 Project Grant under CFDA 93.853, Extramural Research Programs in the Neurosciences and Neurological Disorders, to the Regents of the University of Minnesota, Office of Sponsored Projects Administration. This 2-year grant will fund research using cutting-edge voltage imaging to examine how interactions between specific neuronal circuit elements in the hippocampus relate to the development of temporal lobe...
This federal Project Grant award of $657,958, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to elucidate the cellular and network mechanisms underlying epileptic activity and seizures, as well as investigate the neuronal impact of neurostimulation for treating drug-resistant epilepsy. The 5-year award to Trustees of Boston University...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $400,000.00 in funding to Baylor College of Medicine to investigate the contributions of spreading depolarization (SD) to epilepsy comorbidities and disease progression in Dravet syndrome, a major developmental epileptic encephalopathy. The 5-year project, which began on...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $499,953.00 to Stem Pharm, Incorporated to develop and validate a human stem cell-derived neural organoid model for studying temporal lobe epilepsy (TLE). The project aims to create a reproducible, 96-well plate format organoid model that incorporates microglia to better...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) provides $225,599.00 to the University of Illinois to conduct research on the contributions of sex chromosomes and gonadal hormones in shaping sex differences in epilepsy. The research aims to determine the roles of sex chromosomes and gonadal hormones in acute seizure susceptibility, seizure-induced...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $376,355 to Albany Medical College to study the role of microglial insulin-like growth factor 1 (IGF1) in epileptogenesis. The research aims to characterize how elevated mTOR signaling in microglia leads to increased IGF1 expression, and how this propagates mTOR signaling to...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $390,000.00 to the University of Texas at Dallas (UTD) to conduct research on translational control in focal cortical malformations and epilepsy. The research aims to: 1) determine specific mRNA subsets altered by dysregulated MNK-eIF4E signaling in focal cortical dysplasia type II...
This federal Project Grant award, totaling $582,656.00 and issued on September 18, 2024, supports research on genetic and transcriptomic factors underlying epilepsy in baboons under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program by the National Institute of Neurological Disorders and Stroke (NINDS). The key products and services to be delivered include: (1) identifying epilepsy-risk genetic variants in the baboon genome and characterizing...
This $648,893 Project Grant, awarded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will fund research to investigate spatial recognition memory and its relationship to cognitive deficits in epilepsy patients. The University of California, Davis will use a novel paradigm with photorealistic dynamic scenes to assess familiarity, recollection, and memory...
The federal Project Grant award, funded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research aimed at developing a highly personalized approach to thalamic neuromodulation for treating drug-resistant epilepsy. The $256,500 award, spanning from January 1, 2025 to December 31, 2029, will enable the principal investigator at Mayo Clinic to: 1) map...