This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $390,000.00 to the University of Texas at Dallas to conduct research on translational control in focal cortical malformations and epilepsy. The research aims to determine the specific mRNA subsets altered due to dysregulated MNK-eIF4E signaling, delineate the contribution...
The federal Project Grant award of $657,958.00 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) will support research at Trustees of Boston University to investigate the cellular and network mechanisms underlying epileptic activity and seizures. The research aims to elucidate the neuronal mechanisms of biomarkers associated with epilepsy, such as spike ripples, and gain...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $426,250 Project Grant under CFDA 93.853, Extramural Research Programs in the Neurosciences and Neurological Disorders, to the Regents of the University of Minnesota, Office of Sponsored Projects Administration. This 2-year grant will fund research using cutting-edge voltage imaging to examine how interactions between specific neuronal circuit elements in the hippocampus relate to the development of temporal lobe...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $129,454 to the University of Maryland, Baltimore to study the role of the SUR1-TRPM4 channel in chronic seizure susceptibility. The research aims to define how neuronal expression of this channel contributes to hyperexcitability and seizure activity, with the goal of...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will support research to determine the contributions of sex chromosomes and gonadal hormones in shaping acute seizure susceptibility, seizure-induced neuropathology, spontaneous recurrent seizures, and hippocampal gene expression in a mouse model of temporal lobe epilepsy. The total funding...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $376,355.00 to Albany Medical College to investigate the role of microglial insulin-like growth factor 1 (IGF1) in epileptogenesis. The research aims to characterize how elevated mTOR signaling in microglia leads to increased IGF1 expression, which then propagates mTOR signaling to...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $234,276 over 5 years to the University of California, San Diego (UCSD) to conduct research on predicting outcomes for epilepsy surgery. The project aims to use functional MRI (fMRI) and advanced statistical/machine learning methods to identify associations between brain network...
This $632,243 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to understand the molecular and cellular mechanisms of cerebellar dysfunction in neurodevelopmental disorders (NDDs). The primary goal is to elucidate how disruptions to cerebellar inhibitory neurons, particularly Purkinje cells and GABAergic interneurons,...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to investigate the non-canonical roles of voltage-gated sodium channels (VGSCs) in neurodevelopmental epilepsy. The $145,642 award to The Trustees of Columbia University will fund a 3-year research project examining the influence of SCN3A gene variants on...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, is providing $570,362 to the University of Washington to evaluate the disease-modifying potential of dimethyl fumarate (DMF) for preventing and treating pharmacoresistant epilepsy. The study aims to determine the pharmacokinetic and pharmacodynamic properties of DMF, assess its ability to...