Project Grant R56NS135399

Award Date 9/18/24
Completion Date 8/31/25
Dollars Obligated $583K
Federal Grant Program
93.853
Assistance Type
Project Grant
Place of Performance
San Antonio, TX 78249, USA
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The key products and services to be delivered include: (1) identifying epilepsy-risk genetic variants in the baboon genome and characterizing associated biological pathways; (2) quantifying gene and microRNA expression in epileptic and healthy baboon brains using single-nuclei RNA sequencing; and (3) generating and assessing primary and CRISPR-edited cerebral organoids derived from baboon induced pluripotent stem cells to investigate the effects of the RBFOX1 gene on the transcriptional landscape and synaptic function in epilepsy. The University of Texas Rio Grande Valley is the sub-awardee, contributing bioinformatics and analytical expertise to the project.

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