Project Grant R21NS138981
- This $2,291,595 Project Grant awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports a longitudinal study to determine whether Epstein-Barr virus (EBV)-induced molecular mimicry is a likely cause of multiple sclerosis (MS) in African Americans. The award will fund a study using blood samples collected from over 10 million active duty U.S. military personnel to investigate the relationship...
- This $427,627 Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) to The University of Iowa supports research on the impact of gamma herpesvirus, specifically Epstein-Barr virus (EBV), on the interactions between B cells and CD4 T cells in a mouse model of multiple sclerosis (MS). The research aims to understand how EBV infection may influence the development of autoimmunity and neuroinflammation in MS, a...
- The U.S. Department of Defense's Defense Health Agency awarded a $250,000 Project Grant to Yale University under the Military Medical Research and Development program (CFDA 12.420) to conduct research on "EPSTEIN-BARR VIRUS IN PATIENTS WITH NEW-ONSET MULTIPLE SCLEROSIS". The project will run from July 1, 2024 to June 30, 2026. As a prime grantee, Yale University will lead this scientific research effort to advance knowledge about the relationship between Epstein-Barr virus and the...
- This $320,000 Project Grant award from the U.S. Defense Health Agency under the Military Medical Research and Development program (CFDA 12.420) supports research conducted by The Ohio State University to create a mouse model for investigating how the Epstein-Barr virus (EBV) can reprogram and create pathogenic B cells, which is relevant to understanding the role of EBV in multiple sclerosis. The award period runs from September 1, 2025 to August 31, 2027. This research project aims to advance...
- This Project Grant award of $691,788 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) is focused on understanding the role of the ASB13 protein in the Epstein-Barr virus (EBV) life cycle. The research aims to investigate how ASB13 interacts with the SYK kinase to limit EBV replication, as well as how ASB13 binds and destabilizes the EBV immediate-early protein RTA, leading to its degradation. This work...
- This Project Grant award in the amount of $521,839.00 was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program. The grant supports research at the University of California, San Diego to investigate the molecular mechanisms underlying the activation of microglia, which contribute to oxidative stress and tissue damage in multiple sclerosis (MS)....
- This federal Project Grant award of $319,999.00 from the Defense Health Agency under the Military Medical Research and Development (CFDA 12.420) program supports research at the University of Maryland, Baltimore on the relationship between cortical lesions, meningeal inflammation, and Epstein-Barr virus infection in multiple sclerosis, as observed using 7-T MRI. The award period runs from November 1, 2024 to October 31, 2026. The research aims to advance understanding of the underlying...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $104,433 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to The Washington University in St. Louis to conduct research on examining microglia reactivation in multiple sclerosis (MS). The project aims to define the gene signature of disease-associated microglia (DAM) and understand how the function of these cells is affected by repeated activation, as...
- This federal Project Grant award of $427,104.00, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, is focused on identifying biomarkers of demyelination and remyelination in a mouse model of multiple sclerosis (MS). The key objectives are to profile proteins and lipids in tissue-derived and plasma-derived extracellular vesicles to discover novel biomarkers...
- This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $450,462.00 in funding to the Regents of the University of Minnesota to conduct research on the role of the Epstein-Barr Virus (EBV) nuclear antigen 2 (EBNA2) in transcriptional regulation and its contribution to B-cell transformation and EBV pathogenesis. The research aims to elucidate the mechanisms by which EBNA2...
This Project Grant award, valued at $237,476.00, is funded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The grant supports research to characterize the temporal and spatial expression of Epstein-Barr virus (EBV) and EBV-regulated genes within a specific B cell subset, with the goal of defining the role of EBV in the pathogenesis of multiple sclerosis (MS). The research, conducted by Duke University, aims to determine how EBV may contribute to the expansion or activity of a potentially autoreactive and pro-inflammatory B cell subset associated with high genetic risk for MS. The award has an initial performance period from August 1, 2025 to July 31, 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $237.5k | 7/29/25 |