The U.S. Department of Defense's Defense Health Agency awarded a $250,000 Project Grant to Yale University under the Military Medical Research and Development program (CFDA 12.420) to conduct research on "EPSTEIN-BARR VIRUS IN PATIENTS WITH NEW-ONSET MULTIPLE SCLEROSIS". The project will run from July 1, 2024 to June 30, 2026. As a prime grantee, Yale University will lead this scientific research effort to advance knowledge about the relationship between Epstein-Barr virus and the...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $502,031 to Emory University to investigate the role of Epstein-Barr virus (EBV) in the pathogenesis of Hidradenitis Suppurativa (HS), a chronic inflammatory skin condition. The key objectives are to: 1) Determine the clonal dynamics of B cells and plasma cells in HS skin lesions, 2) Recreate human monoclonal...
This federal Project Grant award, identified as R21AI180281, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The $924,000 award aims to discover and characterize small molecule inhibitors targeting the deubiquitinating activity of the Epstein-Barr virus (EBV) protein BPLF1. The project will utilize high-throughput screening to identify novel chemical compounds as potential therapeutic...
This federal Project Grant award, sponsored by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $425,125 to Brigham & Women's Hospital Inc. to conduct research on understanding how Epstein-Barr virus (EBV) transformed B-cells evade detection and attack by natural killer (NK) cells. The research aims to characterize the role of protocadherin gamma proteins in enabling EBV+ lymphoma cells to...
This $193,375 Project Grant was awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The grant aims to identify genetic drivers of the ESX1 secretion system in Mycobacterium tuberculosis (Mtb) that may contribute to variable treatment responses, even in drug-sensitive TB cases. The research project has two key objectives: 1) Use bacterial genetic approaches to assess the effects of clinically...
This $877,104.00 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research by Brigham & Women's Hospital Inc. to investigate the interactions between Kaposi's sarcoma-associated herpesvirus (KSHV), mononuclear phagocytes, and B cells that contribute to long-term KSHV B cell latency. The research aims to provide new insights into the mechanisms underlying KSHV...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) provides $305,000 to Saint Louis University to conduct research on stem-like T cells and their role in multiple sclerosis (MS). The key objectives are to: Rigorously test the hypothesis that continuing stemness and differentiation of CD4+ T stem cells leads to functional and transcriptomic diversification under autoimmune...
This $658,273 Project Grant awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) will fund research to investigate how Herpes Simplex Virus 1 (HSV-1) interacts with and regulates the NLRP1 inflammasome pathway in human skin cells. The key objectives are to 1) determine how the HSV-1 ICP0 protein activates stress-activated protein kinases and the consequences for NLRP1 inflammasome activation, 2)...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), aims to investigate the role of enteric glial cells (EGCs) in the autoimmune response in experimental autoimmune encephalomyelitis (EAE), a model for multiple sclerosis (MS). The $158,260 award, with a project period from September 2024 to March 2025, will fund research to characterize T cell responses against EGCs in the EAE...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $213,000 Project Grant (CFDA 93.855 - Allergy and Infectious Diseases Research) to the Morehouse School of Medicine, Inc. to investigate the "Role of ASIC1a Activation in ECM Associated Brain Injury and Mortality" related to cerebral malaria. The project will run from May 5, 2025 to April 30, 2027. The Morehouse School of Medicine, a leading private non-profit historically black medical school, will leverage...
This $1,527,730 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) will support a longitudinal study to investigate the relationship between Epstein-Barr virus (EBV) infection and the risk of developing multiple sclerosis (MS) among African Americans. The study will leverage pre-diagnostic serum samples and clinical data from over 480 Black participants (240 men, 240 women) to assess antibody responses to the human virome and proteome, with a focus on molecular mimicry between EBV antigens and autoantigens as a potential mechanism for MS development. The project aims to identify predictive biomarkers that could help prevent MS by modifying the immune response to EBV infection. This research will contribute to bridging the knowledge gap on the causes of MS in the African American population, which has experienced a rise in MS incidence and severity. The project will be conducted by the President and Fellows of Harvard College, specifically through its Harvard T.H. Chan School of Public Health division, and is scheduled for completion by May 2025.