Project Grant R01DE035120
- This $601,309 Project Grant was awarded by the National Institute of Dental and Craniofacial Research (NIDCR), under the federal Oral Diseases and Disorders Research program (CFDA 93.121), to the University of Florida from July 1, 2025 to March 31, 2030. The project aims to identify core mechanisms that disrupt silencing of the Epstein-Barr virus (EBV) BZLF1 gene, in order to increase the responsive fraction of EBV-associated lymphoma cells to oncolytic therapies in people living with HIV. The...
- The University of Michigan received a $183,044 Project Grant from the National Cancer Institute (CFDA 93.398 Cancer Research Manpower program) to support research on resolving how the Epstein-Barr virus (EBV) oncoproteins EBNA3A and EBNA3C coordinate with the cellular regulator EZH2 to drive lymphoproliferation and pathogenic outcomes in EBV-infected cells. This 3-year grant, awarded on February 3, 2025, aims to provide comprehensive high-resolution insights on vulnerabilities in EBV-driven...
- This Project Grant award, valued at $237,476.00, is funded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The grant supports research to characterize the temporal and spatial expression of Epstein-Barr virus (EBV) and EBV-regulated genes within a specific B cell subset, with the goal of defining the role of EBV in the pathogenesis of multiple sclerosis (MS). The...
- This Project Grant award of $691,788 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) is focused on understanding the role of the ASB13 protein in the Epstein-Barr virus (EBV) life cycle. The research aims to investigate how ASB13 interacts with the SYK kinase to limit EBV replication, as well as how ASB13 binds and destabilizes the EBV immediate-early protein RTA, leading to its degradation. This work...
- This $505,056 Project Grant award, funded by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), supports research at the University of California, Davis to understand the relationship between inflammatory signaling and Kaposi's sarcoma-associated herpesvirus (KSHV) replication. The goal is to investigate how cellular inflammatory pathways and viral cytokines like viral IL-6 may contribute to maintaining KSHV...
- This $427,627 Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) to The University of Iowa supports research on the impact of gamma herpesvirus, specifically Epstein-Barr virus (EBV), on the interactions between B cells and CD4 T cells in a mouse model of multiple sclerosis (MS). The research aims to understand how EBV infection may influence the development of autoimmunity and neuroinflammation in MS, a...
- This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), part of the U.S. Department of Health and Human Services, focuses on investigating the role of FOXK transcription factors in Kaposi's sarcoma-associated herpesvirus (KSHV) infection. The $136,631 grant, awarded on January 22, 2025, supports a research project at the University of Florida in Gainesville that aims to dissect the interaction between KSHV's immediate early tegument protein and the FOXK1...
- This Project Grant award of $466,640.00, provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121), supports research to investigate the mechanisms that sustain lytic herpesviral infection in the oral cavity. The key goals are to determine the molecular mechanisms controlling the infection of oral epithelial cells by the Kaposi's sarcoma-associated herpesvirus (KSHV), and how oral KSHV...
- This $2,291,595 Project Grant awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports a longitudinal study to determine whether Epstein-Barr virus (EBV)-induced molecular mimicry is a likely cause of multiple sclerosis (MS) in African Americans. The award will fund a study using blood samples collected from over 10 million active duty U.S. military personnel to investigate the relationship...
- The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $178,000 Project Grant to the Beckman Research Institute of the City of Hope under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121). The grant, awarded on April 1, 2025, supports a 2-year research project to characterize the biogenesis and biological functions of protein phosphoribosylation, a novel post-translational modification, in the context of herpes simplex virus 1 (HSV-1) infection....
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $450,462.00 in funding to the Regents of the University of Minnesota to conduct research on the role of the Epstein-Barr Virus (EBV) nuclear antigen 2 (EBNA2) in transcriptional regulation and its contribution to B-cell transformation and EBV pathogenesis. The research aims to elucidate the mechanisms by which EBNA2 regulates gene expression, identify EBNA2 co-factors, and determine how EBNA2-mediated genome organization impacts B-cell transformation and EBV-associated diseases. This 5-year project, scheduled to run from August 2025 to May 2030, seeks to enhance the understanding of EBV's oncogenic potential and inform the development of targeted therapies for EBV-related diseases.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $450.5k | 8/13/25 |