This National Science Foundation (NSF) Project Grant award, funded under the Engineering program (CFDA 47.041), provides $319,574 to Iowa State University to develop a model for understanding how traveling waves in the brain drive interstitial fluid flow in the porous brain cortex. The overarching goal is to advance the fields of porous media flows, biofluid dynamics, and neuroscience, which could lead to the development of therapeutic strategies against neurological disorders. Key objectives...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $426,250 Project Grant under CFDA 93.853, Extramural Research Programs in the Neurosciences and Neurological Disorders, to the Regents of the University of Minnesota, Office of Sponsored Projects Administration. This 2-year grant will fund research using cutting-edge voltage imaging to examine how interactions between specific neuronal circuit elements in the hippocampus relate to the development of temporal lobe...
This Project Grant award of $2,156,000.00 from the National Institutes of Health (NIH) Trans-NIH Research Support program (CFDA 93.310) supports a research project to develop and validate non-invasive neuroimaging methods for quantifying brain oxygen availability, pH, and carbon dioxide levels. The goal is to better understand the relationship between cerebral blood flow, neuronal metabolic demands, and the regulation of waste products, in order to identify the underlying causes of brain...
This Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), provides $1,244,260.00 to New York University (NYU) to develop an advanced interferometric diffuse optics (IDO) system for quantitatively and specifically measuring cerebral blood flow. The goal is to create a system that can improve the signal-to-noise ratio and channel...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program provides $440,640.00 to the University of Arizona to investigate the use of oscillating electromagnetic fields to modulate glymphatic system activity and brain waste clearance. The research aims to measure the global and regional impacts of slow-wave brain activity entrainment on glymphatic...
This Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), provides $398,342 to the University of California, Davis to develop a novel miniature two-photon microscope that can simultaneously perform calcium imaging and optogenetic manipulation of neural activity in freely behaving mice. The device will integrate advanced optical and...
This Project Grant award of $348,373 from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), aims to develop a novel family of biosensors that can be used to report on and dynamically regulate changes in neuroinflammation within the brains of live animals. The key products and services to be delivered through this grant include: 1) Developing and...
This Project Grant award of $535,416 from the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) aims to develop a technological toolkit that enables noninvasive mapping of ionic activity in the brain of mice. The key products and services to be delivered under this 5-year grant include: Developing a voltage-sensing nanoprobe comprising indocyanine green (ICG) dye...
This federal Project Grant award of $131,085 from the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) supports the development of an ultrasound-interrogated, implantable sensor for non-invasive intracranial pressure (ICP) monitoring. The award will fund research to optimize the sensor design, evaluate its performance with ultrasound, and test the integrated...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support research to investigate brain stiffness as a predictor of characteristics and re-expansion of chronic subdural hematomas (CSDH). The $1,017,307 award will fund a study examining 40 CSDH patients, collecting clinical measures and high-resolution magnetic resonance elastography (MRE) data to correlate brain mechanical properties with hematoma size, density, and brain tissue re-expansion...