This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, is focused on investigating the cellular and molecular mechanisms underlying levodopa-induced dyskinesia (LID) in Parkinson's disease. The $350,036 award to the University of Alabama at Birmingham aims to characterize the unique transcriptional, physical, and physiological changes...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $469,500 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to Michigan Technological University. The grant, titled "Dissecting Neural Circuit Mechanisms Underlying Pallidal Deep Brain Stimulation," will fund research to identify the neural elements and circuits necessary for the therapeutic effects of deep brain stimulation (DBS) of the globus...
This $173,140 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will support research at the University of California, San Francisco (UCSF) to elucidate the role of neural activity in the degeneration of midbrain dopamine neurons associated with Parkinson's disease. The project aims to utilize novel mouse models to chronically manipulate the...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $481,049 to the University of California, San Diego (UCSD) for research focused on understanding the role of substantia nigra circuits in Parkinson's disease. The key goals of this 5-year research project are to: 1) characterize how substantia nigra pars reticulata (SNr)...
This federal Project Grant award of $499,286.59, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to elucidate the relationship between oxidative stress and the LRRK2 protein in the pathogenesis of Parkinson's disease. The 4-year project, with an award period of August 23, 2024 to July 31, 2028, focuses on three broad aims: 1) examining...
This $682,493 federal Project Grant awarded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program supports research to elucidate the role of aberrant histone acetylation in the pathogenesis of Parkinson's disease, Lewy body dementia, and related synucleinopathies. The research team at Albert Einstein College of Medicine in Bronx, NY is employing human pluripotent stem...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $655,329 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to Albert Einstein College of Medicine in Bronx, NY. The grant will fund research to determine the role of the GPNMB gene in the pathogenesis of Parkinson's disease, Lewy body dementia, and related synucleinopathies. The research will integrate genome-wide association study data with epigenetic...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, funds research to investigate the relationship between cortical planning activity and disordered spoken interaction. The $163,184 award to New York University School of Medicine will focus on dissecting the function of the caudal middle frontal gyrus (CMFG), a brain region...
This Project Grant award of $476,643.00, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, will support research to examine the neurophysiological basis of impaired gait in mouse models of Parkinson's disease. The award will enable the University of California, Los Angeles (UCLA) to conduct experiments using high-speed video, automated...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $1,227,794.00 to The Washington University to conduct research on the pathophysiology of Parkinson's disease (PD). The key research objectives are to: 1) evaluate the connectivity between PD-relevant subcortical structures and the somato-cognitive action network (SCAN) versus...