This Project Grant award, with a total funding of $361,454, was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training (CFDA 93.859) program. The grant's objective is to investigate the molecular mechanisms underlying nutritional compensation in the circadian clock, a ubiquitous phenomenon in eukaryotic organisms that helps maintain a 24-hour period length despite fluctuations in external conditions like temperature and nutrient...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training (CFDA 93.859) program, provides $451,250 in funding to the Children's Hospital Medical Center in Cincinnati, Ohio. The project aims to investigate the mechanisms that coordinate clock gene expression within the brain's central pacemaker and distributed brain oscillators, as well as how internal and external signals integrate to regulate circadian rhythms...
This federal Project Grant award of $373,200 was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The grant supports research by the Regents of the University of Michigan to decipher the role of mRNA nuclear localization in regulating circadian rhythms. Key objectives include identifying the sequences responsible for nuclear localization of the timeless...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders CFDA program provides $424,703 to conduct research on circadian timekeeping in Syrian hamster mutants. The project, led by Marquette University, will investigate how changes in molecular clock function translate into phenotype and pathology, leveraging well-characterized circadian clock mutations in the...
This National Science Foundation (NSF) Project Grant, under the Biological Sciences program (CFDA 47.074), provides $240,000 in funding from February 1, 2024 to January 31, 2027 to support a postdoctoral research fellowship focused on investigating a novel circadian time-keeping mechanism revealed by environmental manipulation. The research plan aims to identify the location in the brain and the mechanism of a non-canonical clock that can rescue daily rhythms in mice with disrupted central clock...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $438,915 to Florida State University from June 1, 2025 to May 31, 2030. The award supports research to understand the genetic and molecular basis of circadian rhythms and sleep disorders in mammalian models and humans. Key focus areas include: 1) identifying genetic polymorphisms in human clock genes that...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to understand how intercellular communication in circadian neural circuits generates different phases of circadian output. The $443,736 award to The Washington University in St. Louis will evaluate the hypothesis that two distinct forms of the PDF receptor...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $621,500.00 to develop new methods for combined molecular and ultrastructural imaging of neural cells and tissues. The key objectives are to: Develop detergent-free multicolor immunoprobes using single chain variable antibody fragments (scFvs) to enable correlative light...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), is funding a research project titled "Connecting Circadian Clock Dynamics to Metabolism and Fitness" at the University of Chicago. The $435,126 award, spanning January 2025 to December 2029, aims to quantitatively understand the relationship between the circadian clock and external environmental factors that support...
This federal Project Grant award of $475,475 was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The award will support research at Beth Israel Deaconess Medical Center, Inc. (Bidmc) to investigate the role of circadian-driven complement activation and purinergic signaling as potential triggers of morning migraine. The research aims to define the...