This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $644,008 to investigate the role of non-vesicular lipid transport at endoplasmic reticulum-plasma membrane (ER-PM) contact sites in phosphoinositide signaling during early dendrite development. The research, led by the principal investigator at The Research Foundation For The State...
This Project Grant award, totaling $290,688, is funded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The award supports research at Brandeis University to investigate the role of neuronal primary cilia in regulating the balance of excitation and inhibition in the neocortex. The research aims to determine the source of the neuropeptide somatostatin (SST) that...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will fund research to understand the role of extracellular citrate in neuronal excitability and epileptogenesis in SLC13A5 epilepsy, a rare genetic form of epilepsy. The awardee, Brown University, will conduct experiments to identify the tissue-specific sources of excess citrate, assess the...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $525,436 to the Icahn School of Medicine at Mount Sinai to conduct research on the structural pharmacology of GIRK channel disease mutants. The key objectives are to elucidate the molecular mechanisms underlying the loss of potassium selectivity and G protein-independent...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $1,216,094 in funding to the University of California, San Diego to investigate a novel mechanism of dysfunctional mitophagy (selective autophagy of mitochondria) and its role in brain ischemia-reperfusion injury. The objective is to determine if inactivation of the...
This federal Project Grant award of $169,000 from the National Institute of Neurological Disorders and Stroke (NINDS, CFDA 93.853) will support the development of a comprehensive, open-source, and user-friendly online platform for neurometabolic diseases. The platform will include clinical, biochemical, radiological, and therapeutic data on over 1,600 known neurometabolic diseases. This initiative aims to enhance understanding, clinical management, and research insights into these rare genetic...
This federal Project Grant award of $985,026 from the National Institute of Neurological Disorders and Stroke (NINDS) under CFDA 93.853 - Extramural Research Programs in the Neurosciences and Neurological Disorders, aims to investigate the roles and mechanisms of epitranscriptomic regulation in the development and function of the mammalian nervous system, as well as the pathological consequences of disrupting these processes. The research program will utilize mouse models and human induced...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, aims to develop a new therapy for neurodevelopmental mitochondrial disorders. The $105,625 award to the Icahn School of Medicine at Mount Sinai, from August 1, 2024 to July 31, 2026, will support two main objectives: 1) analyzing how a specific succinyl-CoA precursor is...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $433,159 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to the University of Maryland, Baltimore. The grant, effective August 1, 2024 through June 30, 2029, will fund research to define the precise mechanisms through which calcium-activated chloride channels in brain pericytes contribute to the control of capillary blood flow and how neuronal...
This federal Project Grant award of $364,448.00 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) focuses on investigating the neural functions of glycoprotein sialylation. The research aims to reveal sialylation-mediated mechanisms of glia-neuron coupling, elucidate the role of sialylation in promoting neuronal viability and resistance to oxidative stress, and characterize...
This Project Grant award of $671,775.00 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program will fund a multidisciplinary research effort at the Icahn School of Medicine at Mount Sinai. The project aims to elucidate the structure, function, and regulation of neuronal SLC4 bicarbonate transporters, which play a key role in controlling cellular pH and neuronal excitability. The research will combine structural studies, computational drug discovery, and validation of novel chemical probes in physiologically relevant models to generate fundamental insights into SLC4 transporter mechanisms and develop first-in-class tool compounds to further interrogate their function. The five-year project period runs from July 1, 2025 to June 30, 2030.