This $475,369 federal Project Grant awarded by the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to better understand how microglia (the brain's resident macrophages) are programmed by the brain environment following transplantation. The primary awardee, The Trustees of the University of Pennsylvania, will use single-cell RNA and ATAC sequencing to comprehensively characterize the regulatory mechanisms that cause transplanted macrophages to acquire a microglial identity over time. This highly controlled in vivo model will generate a detailed dataset on the environmental signals, transcription factors, and pathways responsible for microglial state changes. The researchers will also compare the programming of microglia versus peripheral macrophages after transplantation. The project has a period of performance from September 16, 2023 to August 31, 2025 and includes a sub-award to The Children's Hospital of Philadelphia Research Institute to contribute expertise and capabilities. This research aims to fill key knowledge gaps about microglial regulation and identify potential therapeutic targets for brain diseases.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $475.4k | 9/15/23 |
Grant Number | Description | Subgrantee | Prime Award | Dollars Obligated (Click to sort descending) | Updated At (Click to sort ascending) |
|---|---|---|---|---|---|
588586S | The Children's Hospital Of Philadelphia | Project Grant R21NS135366 | $147.8k | 12/21/23 |