This $475,369 federal Project Grant awarded by the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to better understand how microglia (the brain's resident macrophages) are programmed by the brain environment following transplantation. The primary awardee, The Trustees of the University of Pennsylvania, will use single-cell RNA and ATAC sequencing to...
The federal Project Grant award R01NS138309 was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The $653,309 award supports research to develop a novel systemic enzyme delivery system using a brain-targeted SAPC-DOPS nanocarrier for treatment of neuronopathic Gaucher disease. The project, conducted by the Children's Hospital Medical Center in Cincinnati,...
This federal Project Grant award of $686,276.00, made by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to uncover the cellular mechanisms driving Aicardi-Goutieres syndrome (AGS) neuropathology and explore potential treatment approaches. The research team, led by investigators at the Children's Hospital of Philadelphia (CHOP) and the University...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $429,925 to Rosalind Franklin University of Medicine & Science to explore the use of glial progenitor cells for generating dopaminergic neurons as a potential cell therapy for Parkinson's disease. The research aims to directly reprogram adult human oligodendrocyte progenitor...
This $218,068 federal Project Grant awarded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program supports research to understand mechanisms of glial cell recovery and facilitation of axon regeneration after injury. The research, conducted by The Children's Hospital of Philadelphia (CHOP), leverages a larval fly sensory neuron model to investigate the role of glial cell...
This $410,000 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research to uncover the mechanisms underlying glycogen metabolism disorders leading to the formation of polyglucosan bodies. The primary research objectives are to: Utilize newly created mouse models and cell lines to understand the role of the E3 ubiquitin ligase LUBAC in...
This Project Grant award of $419,482.00 from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports pre-clinical testing of a novel gene therapy treatment for pediatric neurodegenerative disease. The primary objectives are to determine the minimum effective dose and post-symptomatic treatment efficacy of the AAV9-HVAC14OPT gene therapy product in mouse models of...
This $246,248 project grant was awarded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program. The grant supports research aimed at understanding how disruptions to the autophagy pathway contribute to inflammation, plaque formation, and disease progression in Alzheimer's disease and related dementias. The research will use innovative stem cell models and...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $461,701 to Tega Therapeutics Inc. to develop and validate an intracerebroventricular (ICV) enzyme replacement therapy for the treatment of GM1 gangliosidosis, a rare lysosomal storage disease affecting the central nervous system. The key objectives are to engineer cell lines to...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $163,750.00 to The Johns Hopkins University to conduct research focused on identifying small molecule enhancers that can boost the activity of the mutant glucocerebrosidase 1 (GBA1) enzyme. The research aims to address the link between GBA1 mutations and Parkinson's disease...