Project Grant R21NS135045

Award Date 8/7/24
Completion Date 6/30/26
Dollars Obligated $246K
Federal Grant Program
93.853
Assistance Type
Project Grant
Place of Performance
Maryland, USA
Similar Awards
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $426,656 Project Grant (CFDA 93.853 - Extramural Research Programs in the Neurosciences and Neurological Disorders) to Creighton University to investigate a novel therapeutic strategy targeting neuroinflammation for global cerebral ischemia associated with cardiac arrest. The research aims to determine the pathological importance of the inflammatory receptor TREM1, elucidate the mechanisms by which global ischemia...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $433,159 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to the University of Maryland, Baltimore. The grant, effective August 1, 2024 through June 30, 2029, will fund research to define the precise mechanisms through which calcium-activated chloride channels in brain pericytes contribute to the control of capillary blood flow and how neuronal...
This $497,196 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program supports the development of a novel magnetic resonance spectroscopic imaging (MRSI) pulse sequence at 3 Tesla. The goal is to simultaneously map both downfield and upfield proton metabolic signals in the human brain, which may provide important new insights into brain metabolism....
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $704,313 to Trustees of Boston University to advance the development of a prognostic and monitoring biomarker for neutrophil-driven secondary brain injury in spontaneous intracerebral hemorrhage (SICH). The project aims to define and validate a standardized flow cytometry...
This $519,500 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program aims to develop and validate a novel glucose-based dendrimer platform for delivering therapeutics specifically to injured neurons. The primary goals are to: 1) determine the mechanisms of glucose-dendrimer uptake in neurons, 2) evaluate the in vivo biodistribution and...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a Project Grant of $438,836 to The Trustees of the Stevens Institute of Technology under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program. The award supports research to develop a unified paradigm using simultaneous multimodal measurement of scalp EEG and intracranial EEG (iEEG) signals to estimate the electrophysiological networks of the whole brain....
The Johns Hopkins University received a $1,490,248 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the 21st Century Cures Act - Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative (CFDA 93.372). The award supports a 3-year research project titled "Cortical Circuit Dynamics Underlying Multisensory Decision Making." The project aims to investigate how the brain integrates visual, vestibular, and kinesthetic...
This $498,995 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program supports the development of a highly parallelized interferometric near-infrared spectroscopy (INIRS) platform for the real-time, non-invasive measurement of cerebral blood flow. The research aims to address the limitations of current stroke diagnosis and monitoring techniques...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $423,500 Project Grant (CFDA 93.853 - Extramural Research Programs in the Neurosciences and Neurological Disorders) to the Augusta University Research Institute, Inc. The objective is to develop and evaluate engineered exosomes carrying neuron-targeting peptides and a therapeutic protein (neuroglobin) for treating ischemic stroke. The research will: 1) characterize the engineered exosomes and assess their...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $1,830,581 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program to The Johns Hopkins University. The grant supports in-depth characterization of the mechanism of action of a new macrocycle molecule called RAPIREON, which selectively activates the nuclease activity of the IRE1 protein in the unfolded protein response (UPR) pathway....

The National Institute of Neurological Disorders and Stroke (NINDS) awarded a Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program to The Johns Hopkins University. The $245,625 award, which runs from August 7, 2024 to June 30, 2026, will fund the "DELTA ECMO ABI STUDY" to investigate the causes of acute brain injury in patients receiving extracorporeal membrane oxygenation (ECMO) therapy. The research aims to determine if rapid changes in carbon dioxide levels during ECMO initiation contribute to brain injury and impact long-term neuropsychiatric outcomes. The study will utilize portable MRI imaging and biomarker analysis to diagnose acute brain injury, with the goal of advancing understanding of this complication and informing future approaches to mitigate it during ECMO treatment.

Generated 7/1/25, 4:47 AM