This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $571,404.00 to the University of Pittsburgh to conduct research aimed at understanding and improving neurological outcomes after traumatic brain injury (TBI). The key research objectives are to: Evaluate the long-term therapeutic potential of an adiponectin receptor agonist in...
This Project Grant award, valued at $404,100.00, was issued by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program. The award will support research by The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), to investigate the mechanisms of chronic blood-brain barrier dysfunction after traumatic brain injury (TBI). The...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $453,860.00 to support research on the metabolic regulation of neutrophil extracellular traps (NETs) in traumatic brain injury (TBI). The 5-year project, beginning June 1, 2025 and ending April 30, 2030, aims to determine the role of AMPK modulation on functional outcomes and...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, will fund research at the Augusta University Research Institute, Inc. (doing business as Georgia Health Sciences) to investigate the mechanisms linking traumatic brain injury (TBI) to subsequent neurodegeneration and dementia. The $1,975,262 award will support a 3-year study...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, supports research to investigate the relationship between traumatic brain injury (TBI), hematopoietic stem cell dysfunction, chronic neurodegeneration, and Alzheimer's disease (AD). The $102,948 award, active from December 1, 2024 to August 31, 2027, will employ a clinically...
This Project Grant award of $2,248,793 from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to investigate the relationship between epigenetic aging and patient outcomes after severe traumatic brain injury (TBI). The University of Pittsburgh is the prime awardee. The key objectives are to expand upon the researchers' preliminary findings that accelerated epigenetic aging, as measured by DNA methylation patterns, is linked to poorer outcomes at 6, 12, and 24...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, is supporting the development of an innovative point-of-care diagnostic device to quickly detect and monitor the severity of traumatic brain injury (TBI). The $332,122 grant awarded to Hemex Health Inc. will fund the creation of a portable, microchip-based platform capable of...
This federal Project Grant award, valued at $405,000.00 and granted by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research focused on understanding the effects of traumatic brain injury (TBI) on serotonin (5-HT) neurotransmission. The research aims to identify and characterize TBI-induced alterations in the transcriptional identity of specific...
This $444,125.00 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will be used by the University of California, San Francisco (UCSF) to conduct research on the brain maturation-dependent mechanisms underlying hemorrhagic transformation after delayed reperfusion in perinatal and childhood ischemic stroke. The key objectives are to: 1)...
This $443,354 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to investigate metabolic dependencies and resistance mechanisms in pediatric diffuse midline glioma (DMG) brain tumors harboring the H3K27M mutation. The research aims to understand how targeting the hexosamine biosynthetic pathway, either alone or in...