Project Grant R21MH144624
- The National Institute of Mental Health awarded the University of North Carolina at Chapel Hill $124,128 on December 15, 2025, under the Mental Health Research Grants program (CFDA 93.242) to characterize trajectories of structure-function coupling in human brain networks from birth through adolescence and examine relationships to transdiagnostic psychopathology. The project leverages the UNC Early Brain Development Study, a longitudinal dataset with ten timepoints of diffusion and resting-state...
- The National Institute of Mental Health awarded the University of North Carolina at Chapel Hill $420,552 on August 3, 2026, under the Mental Health Research Grants program (CFDA 93.242) to identify precise brain regions and cell types associated with obsessive-compulsive disorder, Tourette syndrome, and anorexia nervosa using genomic analysis. The recipient will combine the latest genome-wide association study data for these three disorders with single-cell gene expression atlases to enhance...
- The National Institute of Mental Health awarded Cold Spring Harbor Laboratory $528,000 on June 19, 2026, under the Mental Health Research Grants program (CFDA 93.242) to support developmental characterization of synapses between neurons and oligodendrocyte precursor cells. The funded research investigates structural, functional, and molecular properties of neuron-OPC synapses, a class of synaptic connections that remain poorly understood despite evidence that oligodendrocyte precursor cells...
- This $408,541 Project Grant was awarded by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) to Drexel University in Pennsylvania. The grant supports research to investigate the role of a subpopulation of neurons in the retrosplenial cortex in initiating sleep patterns that facilitate memory consolidation. The key objectives are to study the neural dynamics of these "Down-State Assembly" neurons and their involvement in...
- The National Institute of Mental Health awarded the University of Wisconsin–Madison $427,625 on April 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to enhance sleep spindle activity through thalamic temporal interference transcranial electric stimulation (TI-TES) as a potential therapeutic approach for schizophrenia spectrum disorder. The project addresses sleep spindle deficits, which serve as a biomarker reflecting dysfunction in thalamocortical circuits. The...
- The National Institute of Mental Health awarded Cold Spring Harbor Laboratory $897,709 under the Mental Health Research Grants program (CFDA 93.242) on September 1, 2026, for investigation of the molecular mechanisms underlying assembly of axo-axonic synapses in the cerebral cortex. The project focuses on synaptic connectivity between excitatory pyramidal neurons and inhibitory GABAergic interneurons, specifically chandelier cells (axo-axonic cells). Chandelier cells form synapses exclusively at...
- The National Institute of Mental Health awarded Boston Children's Hospital $153,560 on January 7, 2027, under the Mental Health Research Grants program (CFDA 93.242) to conduct a postdoctoral fellowship examining the relationship between sleep physiology, myelin content, and depressive symptoms in young people ages 9–26 years. The research leverages data from two ongoing R01 studies to investigate two specific aims: understanding the relationship between sleep EEG signatures (spindles and slow...
- The National Institute of Mental Health awarded Duke University $315,364 on November 1, 2025, under the Mental Health Research Grants program (CFDA 93.242) to support research on circuit-specific plasticity mechanisms for habitual behavior. The project, titled "Circuit-Specific Plasticity Mechanisms for Habitual Behavior," investigates how cortical inputs to the striatum undergo long-lasting modifications during the transition from goal-directed to habitual action strategies. The...
- The National Institute of Mental Health awarded the Research Foundation For Mental Hygiene, Inc. (Nathan S Kline Institute) $745,840 on May 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to define optimal timing and cognitive states for memory consolidation during wakefulness and test causal mechanisms for targeted memory modulation. The research determines when memory consolidation maximally occurs during post-learning wakefulness by systematically decomposing awake...
- The National Institute of Mental Health awarded $442,750 to the University of California, Davis on July 1, 2026 under the Mental Health Research Grants program (CFDA 93.242) to investigate synaptic plasticity and signaling mechanisms in 22Q11.2 deletion syndrome model mice. The research addresses learning and memory deficits in 22Q11.2 deletion syndrome, the most common chromosomal microdeletion in humans (incidence approximately 1 in 4,000 live births), which presents broad symptoms including...
The National Institute of Mental Health awarded the University of North Carolina at Chapel Hill $427,625 on August 14, 2026, under the Mental Health Research Grants program (CFDA 93.242) to define the synaptic translatome—newly synthesized proteins localized at neuronal synapses—and uncover how sleep and circadian rhythms regulate protein synthesis at these sites, which are central to learning, memory, and synaptic homeostasis. The research addresses the intersection of sleep, synaptic development, and neurodevelopmental disorders such as autism spectrum disorder and schizophrenia, examining how circadian clocks and sleep need coordinate the trafficking of messenger RNAs to synapses and the timing of their translation. The award funds work through August 13, 2028, with performance at Chapel Hill, North Carolina. This R21 exploratory grant mechanism supports hypothesis-driven basic and translational research investigating sleep's biochemical basis and its interactions with circadian mechanisms in neurons.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $427.6k | 8/18/26 |