Project Grant R21MH141468
- The National Institute of Mental Health awarded California Institute of Technology $1,417,650 on September 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to develop instrumentation for synchronized multimodal recording and analysis of human behavior and neural activity during complex, unstructured tasks. The project develops a system to acquire and synchronize behavioral data streams including head-mounted eye tracking to monitor gaze position, egocentric and...
- This $3.21 million cooperative agreement from the National Institutes of Health's National Institute of Neurological Disorders and Stroke will fund research at the California Institute of Technology to develop whole-brain functional imaging and analysis tools to study sleep regulation in zebrafish. Over a three-year period from May 2022 to April 2025, the awardee will use two-photon selective plane illumination microscopy to record neuronal activity with single-cell resolution during natural and...
- The National Institute of Mental Health awarded Scripps Research Institute $878,601 on April 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to support structural remodeling of neural circuits via multisynaptic boutons. The research uses three-dimensional electron microscopy at nanometer resolution to reconstruct neuronal connectomes, individual synapses, and glia in the mammalian brain. The work combines 3D-EM with chemogenetic techniques for labeling cellular ensembles...
- The National Institute of Mental Health awarded Children's Research Institute $654,005 on June 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate the function of paralaminar amygdala neurons from adolescence to adulthood using a mouse model. The recipient will examine how paralaminar nucleus neuronal responses change over the adolescent-to-early-adulthood transition, determine the necessity and sufficiency of these neurons in that transition, and characterize...
- The National Institute of Mental Health awarded the University of Southern California $751,034 on August 6, 2026, under the Mental Health Research Grants program (CFDA 93.242) to support a neuroscience research project examining how the brain processes uncertainty in noisy, dynamically changing environments. The project, titled "Unraveling Neural Mechanisms Underlying Learning in a Noisy, Dynamically Changing World," investigates computational and neural mechanisms by which the brain...
- The National Institute of Mental Health awarded the University of California, San Diego $399,950 under the Mental Health Research Grants program (CFDA 93.242) on August 1, 2026, to investigate reactive oxygen species–mitochondrial–calcium axes in neuronal function. The award funds basic research into the molecular mechanisms underlying neuronal physiology, with potential implications for understanding mental health disorders. The project extends through April 30, 2031, and is performed in La...
- The National Institute of Mental Health awarded Yale University $838,378 on March 10, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate the neural circuits regulating infant social behaviors and learning, with focus on somatostatin-expressing neurons in the zona incerta (ZISST neurons) in preweaning mice. The research comprises three aims. Aim 1 will determine activity dynamics of ZISST neurons in response to maternal behaviors using fiber photometry and...
- The National Institute of Mental Health awarded The Leland Stanford Junior University $734,707 on August 13, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate the coordinated maturation of neurons and synapses in the adolescent human neocortex. The research develops a pipeline to retrieve and analyze tissue specimens resected during pediatric neurosurgical procedures for epilepsy, vascular malformations, or brain tumors. The study examines whether postnatal...
- The National Institute of Mental Health awarded the University of California, Los Angeles $444,845 under the Mental Health Research Grants program (CFDA 93.242) on September 1, 2026, to conduct a two-year study examining intra-individual determinants of neural oscillation phenomena. The funded research deploys multi-sensor measurements to concurrently capture objective measures of arousal (heart rate, heart rate variability, galvanic skin response, pupil metrics), motor activation (body, limb,...
- The National Institute of Mental Health awarded The Leland Stanford Junior University $426,991 under the Mental Health Research Grants program (CFDA 93.242) on August 3, 2026, to support research decoding medial prefrontal cortex (MPFC) plasticity across developmental life stages. The recipient is investigating critical periods of synaptic plasticity in the MPFC using high-throughput assays measuring long-term potentiation in mouse brain slices via multielectrode recording arrays. Aim 1 maps...
The National Institute of Mental Health awarded California Institute of Technology $467,500 on August 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate mechanisms of hypothalamic neuronal circuit development in zebrafish larvae. The research will map the architecture and connectivity of hypothalamic neurons expressing hypocretin, a neuropeptide that promotes arousal in both zebrafish and mammals. Using the Brainbow technique, researchers will label individual hypocretin neurons (10–15 cells per larval zebrafish) with distinct colors and generate single-neuron-level anatomical maps of neuronal projections. The project will examine how these circuits form and are maintained, addressing questions about neuronal circuit development within the brain that remain largely unexplored despite decades of work on sensory and motor systems. The research targets arousal regulation because it is clinically significant for disorders including narcolepsy, Parkinson's disease, and Alzheimer's disease. Zebrafish serve as the model organism because their hypothalamic arousal-regulating nuclei are anatomically, molecularly, and functionally conserved with mammalian counterparts, and the organism permits live imaging and optogenetic and chemogenetic manipulations. Performance occurs in Pasadena, California. The project period runs through July 31, 2028. The award type is a Project Grant, classified as civilian basic research funding.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $467.5k | 8/4/26 |