Project Grant R21MH141229
Award Date 8/12/26
Completion Date 8/11/28
Dollars Obligated $410K
Federal Agency
Federal Grant Program
Assistance Type
Project Grant
Place of Performance
Pennsylvania, USA
Similar Awards
- The National Institute of Mental Health awarded Emory University a project grant of $100,228 on November 8, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate the role of the lateral septum–ventral tegmental area projection in shaping reward learning. The project will use cellular resolution calcium imaging of the lateral septum–ventral tegmental area population during operant behavioral assays to determine whether the lateral septum modulates reward-seeking...
- The National Institute of Mental Health awarded the University of Pittsburgh $158,960 on January 21, 2027, under the Mental Health Research Grants program (CFDA 93.242) to investigate inhibitory control of dendritic spikes in hippocampal CA1 pyramidal neurons. The project will use optogenetics, two-photon calcium imaging, and voltage imaging to explore how dendrite-targeting somatostatin interneurons regulate dendritic spike dynamics, specifically examining how synaptic inhibition modifies...
- The National Institute of Mental Health awarded Scripps Research Institute $878,601 on April 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to support structural remodeling of neural circuits via multisynaptic boutons. The research uses three-dimensional electron microscopy at nanometer resolution to reconstruct neuronal connectomes, individual synapses, and glia in the mammalian brain. The work combines 3D-EM with chemogenetic techniques for labeling cellular ensembles...
- The National Institute of Mental Health awarded Northeastern University $157,500 on September 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to explore the role of microglia in developmental effects of early life adversity on prefrontal cortex glutamate receptor development. The research investigates how microglia, resident immune cells of the brain, drive changes in NMDA receptor expression in adolescents exposed to early life adversity such as maternal separation. Prior...
- The National Institute of Mental Health awarded Emory University $100,228 on December 30, 2026, under the Mental Health Research Grants program (CFDA 93.242) to support research on integrated mechanisms for corticostriatal control of action. The award funds investigation of how the orbitofrontal cortex, premotor cortex, and dorsomedial striatum interact to coordinate exploration-exploitation decision-making—the balance between trying new strategies and leveraging proven approaches. The...
- The National Institute of Mental Health awarded The Trustees of Columbia University in the City of New York $244,428 on August 20, 2026, under the Mental Health Research Grants program (CFDA 93.242) to conduct research on cholinergic modulation of thalamocortical projections to prefrontal cortex in cognitive flexibility. The research will determine whether acute adult cholinergic modulation in the prefrontal cortex modulates attentional set-shifting performance and whether enhancing...
- The National Institute of Mental Health awarded $1.579 million to the Research Foundation For Mental Hygiene, Inc., operating as the New York State Psychiatric Institute, on July 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to fund basic neuroscience research into the circuit mechanisms by which early-life adversity produces sustained reward deficits. The research examines how childhood trauma—including abuse, neglect, and chronic stress—alters neural circuits governing...
- Federal Grant Award Summary The National Institute of Mental Health (NIMH) awarded the University of Pennsylvania a $2,693,038 Project Grant under the Mental Health Research Grants program (CFDA 93.242) for the period September 1, 2025 through August 31, 2029. The award funds research investigating the role of striatal interneurons in behavioral control and value-based decision-making. The project will employ viral-genetic tools and a head-fixed, value-based choice task to systematically examine...
- The National Institute of Mental Health awarded the University of Pittsburgh $705,236 on September 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate spatially-organized prefrontal circuits regulating fear expression and discrimination. The research examines how the rostral and caudal prelimbic cortex of the mouse brain differentially regulate fear responses to threats versus non-threats. The work addresses the pathogenesis of anxiety and trauma-related...
- The National Institute of Mental Health awarded The Trustees of The University of Pennsylvania $762,440 on April 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to develop and validate a concurrent transcranial magnetic stimulation and functional MRI protocol for measuring the effects of continuous theta burst stimulation to the right dorsolateral prefrontal cortex on anxiety-related neural and behavioral responses. The protocol will assess TMS-evoked BOLD responses and...