Project Grant R01MH142649
- The National Institute of Mental Health awarded the University of Pittsburgh $158,960 on January 21, 2027, under the Mental Health Research Grants program (CFDA 93.242) to investigate inhibitory control of dendritic spikes in hippocampal CA1 pyramidal neurons. The project will use optogenetics, two-photon calcium imaging, and voltage imaging to explore how dendrite-targeting somatostatin interneurons regulate dendritic spike dynamics, specifically examining how synaptic inhibition modifies...
- The National Institute of Mental Health awarded the University of Pittsburgh $437,250 on April 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate parvalbumin interneuron diversity and plasticity in primary visual and prefrontal cortical areas. The award funds a two-year exploratory research project running through March 31, 2028, conducted in Pittsburgh, Pennsylvania. The research uses patch-seq methodology to integrate single-cell RNA sequencing,...
- The National Institute of Mental Health awarded the University of Pittsburgh $1,004,971 through the Mental Health Research Grants program (CFDA 93.242) on April 8, 2026, to develop a platform for measuring and analyzing brain activity, cognitive states, behavior, and physiology during multiday neural recordings in individuals undergoing surgical treatment for epilepsy. The project will integrate wearable technology and artificial intelligence for behavioral and physiological monitoring alongside...
- The National Institute of Mental Health awarded the University of Pittsburgh $458,433 on September 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to develop, refine, and validate a developmentally-tailored and ecologically-valid adolescent emotional faces stimulus set and examine the extent to which adolescents' socioaffective processing of these stimuli predicts unique variance in symptoms of anxiety, depression, suicidal ideation, and lifetime history of suicidal...
- The National Institute of Mental Health awarded The Trustees of The University of Pennsylvania $762,440 on April 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to develop and validate a concurrent transcranial magnetic stimulation and functional MRI protocol for measuring the effects of continuous theta burst stimulation to the right dorsolateral prefrontal cortex on anxiety-related neural and behavioral responses. The protocol will assess TMS-evoked BOLD responses and...
- The National Institute of Mental Health awarded the Trustees of Indiana University $436,006 on September 1, 2026, to investigate circuit operation underlying fear memory processes in the amygdala under the Mental Health Research Grants program (CFDA 93.242). The award funds research into the neural mechanisms regulating defensive behaviors and fear memory formation in the amygdala. Current models posit that the lateral amygdala serves as the primary input site for sensory information during fear...
- The National Institute of Mental Health awarded the University of Miami $731,258 on March 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to map neural dynamics linked to major depressive disorder and generalized anxiety disorder using high-stakes real-world events. The recipient will conduct fMRI neuroimaging across five sessions with 144 undergraduate participants—72 diagnosed with GAD or MDD and 72 controls—leveraging naturally occurring emotional events during...
- The National Institute of Mental Health awarded The Trustees of Princeton University $152,600 under the Mental Health Research Grants program (CFDA 93.242) on November 1, 2026, to conduct neural decoding research on biases in latent cause inference during fear extinction in anxiety disorders. The research leverages computational frameworks and neural decoding from optically-pumped magnetoencephalography (OPM-MEG) in combination with physiological markers including skin conductance response and...
- The National Institute of Mental Health awarded The Washington University $735,920 on June 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate neural mechanisms of threat learning and avoidance behaviors. The research elucidates the temporal dynamics and causal roles of neurons in the supramammillary nucleus during threat learning, avoidance, and extinction using fiber photometry, optogenetics, and behavioral assays. The project determines whether these...
- The National Institute of Mental Health awarded the University of Massachusetts Medical School $612,425 on March 15, 2026, under the Mental Health Research Grants program (CFDA 93.242) to conduct longitudinal imaging research on visual discrimination and anxiety in children. The project investigates how high trait anxiety in children is associated with threat misattribution—the tendency to perceive nonthreatening stimuli, particularly faces, as threatening. The research focuses on the...
The National Institute of Mental Health awarded the University of Pittsburgh $705,236 on September 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate spatially-organized prefrontal circuits regulating fear expression and discrimination. The research examines how the rostral and caudal prelimbic cortex of the mouse brain differentially regulate fear responses to threats versus non-threats. The work addresses the pathogenesis of anxiety and trauma-related disorders, in which patients exhibit overgeneralized fear responses to stimuli that do not pose actual threats. The project will map prelimbic neural responses during fear discrimination using in vivo two-photon calcium imaging, label neurons projecting to the basolateral amygdala and periaqueductal gray to characterize their rostrocaudal organization, investigate the functional roles of rostral and caudal prelimbic regions in constraining overgeneralized responses using optogenetics, and map differences in connectivity and transcriptomic expression along the rostrocaudal axis of the prelimbic cortex. The award is a Project Grant, the standard assistance type for investigator-initiated research under NIMH's portfolio. Performance occurs in Pittsburgh, Pennsylvania, with a period of performance extending through May 31, 2031.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $705.2k | 9/3/26 |