Project Grant R21MH140313
- The National Institute of Mental Health awarded the University of Massachusetts Medical School $612,425 on March 15, 2026, under the Mental Health Research Grants program (CFDA 93.242) to conduct longitudinal imaging research on visual discrimination and anxiety in children. The project investigates how high trait anxiety in children is associated with threat misattribution—the tendency to perceive nonthreatening stimuli, particularly faces, as threatening. The research focuses on the...
- The National Institute of Mental Health awarded New York University $855,442 on September 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to characterize neural signatures of anxiety risk in infancy through longitudinal investigation of the mismatch negativity response as a potential biomarker. The project, titled "Characterizing Neural Signatures of Anxiety Risk in Infancy," recruits 250 mother-infant dyads at high risk for anxiety (with half of mothers carrying...
- The National Institute of Mental Health awarded the University of Miami $731,258 on March 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to map neural dynamics linked to major depressive disorder and generalized anxiety disorder using high-stakes real-world events. The recipient will conduct fMRI neuroimaging across five sessions with 144 undergraduate participants—72 diagnosed with GAD or MDD and 72 controls—leveraging naturally occurring emotional events during...
- The National Institute of Mental Health awarded The Trustees of The University of Pennsylvania $762,440 on April 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to develop and validate a concurrent transcranial magnetic stimulation and functional MRI protocol for measuring the effects of continuous theta burst stimulation to the right dorsolateral prefrontal cortex on anxiety-related neural and behavioral responses. The protocol will assess TMS-evoked BOLD responses and...
- The National Institute of Mental Health awarded Children's Research Institute $654,005 on June 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate the function of paralaminar amygdala neurons from adolescence to adulthood using a mouse model. The recipient will examine how paralaminar nucleus neuronal responses change over the adolescent-to-early-adulthood transition, determine the necessity and sufficiency of these neurons in that transition, and characterize...
- The National Institute of Mental Health awarded Northeastern University $157,500 on September 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to explore the role of microglia in developmental effects of early life adversity on prefrontal cortex glutamate receptor development. The research investigates how microglia, resident immune cells of the brain, drive changes in NMDA receptor expression in adolescents exposed to early life adversity such as maternal separation. Prior...
- The National Institute of Mental Health awarded New York University $837,599 on August 11, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate amygdala circuitry and fearful temperament in infants as a risk pathway for anxiety and related mental health challenges. The research identifies amygdala connectivity patterns associated with fearful temperament across the first two years of life, characterizes longitudinal changes in amygdala connectivity, and examines how...
- The National Institute of Mental Health (NIMH) awarded Massachusetts General Hospital a $1.46M Project Grant under the Mental Health Research Grants program (CFDA 93.242) on September 15, 2025, to develop and implement a novel therapeutic intervention combining real-time functional magnetic resonance imaging (fMRI) neurofeedback with mindfulness-based training to address repetitive negative thinking (RNT) in adolescents at risk for serious mental illness. The 24-month project will deliver a...
- The National Institute of Mental Health awarded the University of California, San Diego $2.115 million on August 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to develop and evaluate a mobile health system delivering just-in-time adaptive interventions based on dialectical behavior therapy principles for young adults with comorbid major depressive disorder, social anxiety disorder, generalized anxiety disorder, and related anxiety conditions. The UNDERSTAND project...
- The National Institute of Mental Health awarded the University of Massachusetts Medical School $329,670 on September 15, 2025, under the Mental Health Research Grants program (CFDA 93.242) to develop and evaluate REACHING CALM, a digital intervention employing anxiety sensitivity cognitive-behavioral techniques to prevent perinatal anxiety disorders in individuals with low socioeconomic status. The K23 award supports advanced research training, protected time, mentorship, and research experience...
The National Institute of Mental Health awarded the University of Massachusetts Medical School $474,500 on August 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate the relationship between puberty, interoceptive neural networks, and anxiety symptoms in adolescents. The research employs functional magnetic resonance imaging to characterize how pubertal changes to cortical body representation in primary somatosensory and insular cortices relate to interoceptive function and anxiety symptoms. The cross-sectional study recruits 75 youth ages 11–15 who complete anxiety and pubertal development assessments, MRI scanning including emotional cardiac interoceptive fMRI and resting-state protocols, electrocardiogram testing to assess interoceptive capacity, and behavioral tasks measuring body representation. The award supports a period of performance from August 1, 2026, through July 31, 2028, with place of performance in Worcester, Massachusetts. This Project Grant (assistance type) is classified under NIMH's Mental Health Research Grants program, which funds basic and clinical research to transform understanding and treatment of mental illness.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $474.5k | 8/3/26 |