Project Grant R01MH145306
- The National Institute of Mental Health awarded New York University $837,599 on August 11, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate amygdala circuitry and fearful temperament in infants as a risk pathway for anxiety and related mental health challenges. The research identifies amygdala connectivity patterns associated with fearful temperament across the first two years of life, characterizes longitudinal changes in amygdala connectivity, and examines how...
- The National Institute of Mental Health awarded the University of Massachusetts Medical School $612,425 on March 15, 2026, under the Mental Health Research Grants program (CFDA 93.242) to conduct longitudinal imaging research on visual discrimination and anxiety in children. The project investigates how high trait anxiety in children is associated with threat misattribution—the tendency to perceive nonthreatening stimuli, particularly faces, as threatening. The research focuses on the...
- The National Institute of Mental Health awarded the University of Massachusetts Medical School $474,500 on August 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate the relationship between puberty, interoceptive neural networks, and anxiety symptoms in adolescents. The research employs functional magnetic resonance imaging to characterize how pubertal changes to cortical body representation in primary somatosensory and insular cortices relate to...
- The National Institute of Mental Health awarded the University of Miami $731,258 on March 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to map neural dynamics linked to major depressive disorder and generalized anxiety disorder using high-stakes real-world events. The recipient will conduct fMRI neuroimaging across five sessions with 144 undergraduate participants—72 diagnosed with GAD or MDD and 72 controls—leveraging naturally occurring emotional events during...
- The National Institute of Mental Health awarded Vanderbilt University $106,228 on November 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate associations between cortical microstructure in early infancy and later temperamental negative affectivity and psychopathology symptoms. The research examines neural correlates of negative affectivity (characterized by frequent and intense negative emotional responses such as fear, sadness, and frustration) in infants...
- The National Institute of Mental Health awarded The Administrators of Tulane Educational Fund (Tulane University) $1.233 million on March 15, 2026, under the Mental Health Research Grants program (CFDA 93.242) to examine social and neural pathways linking parental anxiety with youths' daily emotions. The research investigates whether parental threat communication—fearful and negative verbal and nonverbal expressions—mediates the relationship between parental anxiety and children's anxiety during...
- The National Institute of Mental Health awarded New York University $435,974 on May 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to develop computational models that quantify individual differences in learning and decision-making and predict psychiatric symptoms. The award funds development of a novel computational framework combining recurrent neural networks and dynamical systems theory to model reward learning processes at the individual level rather than group...
- The National Institute of Mental Health awarded Children's Research Institute $654,005 on June 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate the function of paralaminar amygdala neurons from adolescence to adulthood using a mouse model. The recipient will examine how paralaminar nucleus neuronal responses change over the adolescent-to-early-adulthood transition, determine the necessity and sufficiency of these neurons in that transition, and characterize...
- The National Institute of Mental Health awarded New York University $771,272 on March 15, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate neuroplasticity of the human maternal brain during pregnancy and its relationship to perinatal mood and anxiety disorders (PMADs). The research examines trajectories of brain structural and functional changes across pregnancy, the role of brain iron in maternal neuroplasticity and PMAD symptoms, and associations between...
- The National Institute of Mental Health awarded The Trustees of The University of Pennsylvania $762,440 on April 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to develop and validate a concurrent transcranial magnetic stimulation and functional MRI protocol for measuring the effects of continuous theta burst stimulation to the right dorsolateral prefrontal cortex on anxiety-related neural and behavioral responses. The protocol will assess TMS-evoked BOLD responses and...
The National Institute of Mental Health awarded New York University $855,442 on September 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to characterize neural signatures of anxiety risk in infancy through longitudinal investigation of the mismatch negativity response as a potential biomarker. The project, titled "Characterizing Neural Signatures of Anxiety Risk in Infancy," recruits 250 mother-infant dyads at high risk for anxiety (with half of mothers carrying an anxiety diagnosis) and follows them across the first two years of life. The research uses event-related potential measurement to evaluate how involuntary attention to environmental change, indexed by mismatch negativity, predicts anxiety trajectories in at-risk infants. The study characterizes developmental trajectories of this neural marker in infants with and without genetic risk for anxiety and evaluates how caregiving and the infant's environment influence the marker's expression and predictive value. NYU School of Medicine, performing the work in New York, New York, manages the award. The period of performance extends from September 1, 2026, through May 31, 2031. The assistance type is a Project Grant, consistent with NIMH support for specified project periods not to exceed five years.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $855.4k | 8/27/26 |