Project Grant R01MH142533
- The National Institute of Mental Health awarded New York University $855,442 on September 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to characterize neural signatures of anxiety risk in infancy through longitudinal investigation of the mismatch negativity response as a potential biomarker. The project, titled "Characterizing Neural Signatures of Anxiety Risk in Infancy," recruits 250 mother-infant dyads at high risk for anxiety (with half of mothers carrying...
- The National Institute of Mental Health awarded Vanderbilt University $106,228 on November 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate associations between cortical microstructure in early infancy and later temperamental negative affectivity and psychopathology symptoms. The research examines neural correlates of negative affectivity (characterized by frequent and intense negative emotional responses such as fear, sadness, and frustration) in infants...
- The National Institute of Mental Health awarded the University of Massachusetts Medical School $612,425 on March 15, 2026, under the Mental Health Research Grants program (CFDA 93.242) to conduct longitudinal imaging research on visual discrimination and anxiety in children. The project investigates how high trait anxiety in children is associated with threat misattribution—the tendency to perceive nonthreatening stimuli, particularly faces, as threatening. The research focuses on the...
- The National Institute of Mental Health awarded Children's Research Institute $654,005 on June 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate the function of paralaminar amygdala neurons from adolescence to adulthood using a mouse model. The recipient will examine how paralaminar nucleus neuronal responses change over the adolescent-to-early-adulthood transition, determine the necessity and sufficiency of these neurons in that transition, and characterize...
- The National Institute of Mental Health awarded $1.579 million to the Research Foundation For Mental Hygiene, Inc., operating as the New York State Psychiatric Institute, on July 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to fund basic neuroscience research into the circuit mechanisms by which early-life adversity produces sustained reward deficits. The research examines how childhood trauma—including abuse, neglect, and chronic stress—alters neural circuits governing...
- The National Institute of Mental Health awarded the University of Massachusetts Medical School $474,500 on August 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate the relationship between puberty, interoceptive neural networks, and anxiety symptoms in adolescents. The research employs functional magnetic resonance imaging to characterize how pubertal changes to cortical body representation in primary somatosensory and insular cortices relate to...
- The National Institute of Mental Health awarded New York University $771,272 on March 15, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate neuroplasticity of the human maternal brain during pregnancy and its relationship to perinatal mood and anxiety disorders (PMADs). The research examines trajectories of brain structural and functional changes across pregnancy, the role of brain iron in maternal neuroplasticity and PMAD symptoms, and associations between...
- The National Institute of Mental Health awarded Yale University $838,378 on March 10, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate the neural circuits regulating infant social behaviors and learning, with focus on somatostatin-expressing neurons in the zona incerta (ZISST neurons) in preweaning mice. The research comprises three aims. Aim 1 will determine activity dynamics of ZISST neurons in response to maternal behaviors using fiber photometry and...
- Federal Grant Award Summary The National Institute of Mental Health (NIMH) awarded a $433,125 Project Grant to the University of California, Los Angeles under the Mental Health Research Grants program (CFDA 93.242) for a two-year project period from September 18, 2025 to September 17, 2027. This research initiative investigates the asymmetrical development of early B cell factor gene 1 (EBF1)-positive cells in the central amygdala and their functional consequences in emotion regulation and...
- The National Institute of Mental Health awarded New York University $435,974 on May 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to develop computational models that quantify individual differences in learning and decision-making and predict psychiatric symptoms. The award funds development of a novel computational framework combining recurrent neural networks and dynamical systems theory to model reward learning processes at the individual level rather than group...
The National Institute of Mental Health awarded New York University $837,599 on August 11, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate amygdala circuitry and fearful temperament in infants as a risk pathway for anxiety and related mental health challenges. The research identifies amygdala connectivity patterns associated with fearful temperament across the first two years of life, characterizes longitudinal changes in amygdala connectivity, and examines how prenatal maternal stress and psychopathology influence infant amygdala connectivity and fearful temperament. The work evaluates how maternal anxiety moderates these associations and tests reproducibility of findings across samples. The study leverages two datasets: the ENIGMA-ORIGINS global infant MRI database (1,479 participants, including 341 with longitudinal MRI data) and the Healthy Brain and Child Development study (5,025 participants), both containing infant MRI scans, parent reports of infant temperament, and maternal perceived stress measures. The HBCD study additionally provides observed assessments of fearfulness and prenatal maternal psychopathology data. New York University School of Medicine, based in New York, New York, is the recipient. The award period runs through April 30, 2031. The assistance type is a Project Grant, which supports specified research projects typically for up to five years under the NIMH portfolio.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $837.6k | 8/13/26 |