Project Grant R21MH137701
Award Date 9/24/25
Completion Date 9/23/27
Dollars Obligated $359K
Federal Agency
Federal Grant Program
Assistance Type
Project Grant
Place of Performance
Washington, USA
Similar Awards
- This federal Project Grant award of $545,759 was provided by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242). The award supports research to determine whether and how enhancing serotonin transmission in the mouse infralimbic medial prefrontal cortex during adolescence can suppress activity in somatostatin neurons and enhance fear extinction in adolescents and adults. This research aims to improve understanding of the serotonin-mediated...
- This Project Grant award of $444,125.00 from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), will support research at George Washington University to investigate the role of serotonergic neurons in alterations to social behavior following early life adversity. The project aims to use electrophysiology, behavioral assays, and fiber photometry to examine how early life stress affects the excitability of serotonergic neurons and...
- This federal Project Grant award of $136,050.00, provided by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), supports research to investigate how a specific protein, BTBD11, regulates the function and composition of glutamatergic synapses in interneurons. The research aims to elucidate the role of BTBD11 and liquid-liquid phase separation in maintaining the unique properties of glutamatergic synapses in interneurons, which are...
- This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $659,217 to develop a novel microelectrode sensor to continuously measure endogenous neuropeptide Y (NPY) release in brain tissue and single cells. The primary objective is to enhance detection of NPY, a key neuropeptide implicated in neurological disorders, by optimizing an existing NPY biosensor to improve sensitivity and selectivity while...
- This Project Grant award of $711,897.00 from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants (CFDA 93.242) program supports research to explore the role of serotonin in modulating aggressive and prosocial behaviors. The key research objectives are to: Characterize the temporal dynamics of serotonin's effects on aggression and prosocial behavior using optogenetic manipulations and serotonin sensor recordings. Identify the specific subpopulations of neurons...
- This federal Project Grant award of $132,462 from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) is funding research at Yale University to understand the neural substrates underlying the encoding of temporal threat proximity and temporally accurate defensive responses to threat. The research seeks to determine the roles of norepinephrine, second messengers, and prefrontal neurons in encoding threat proximity information and...
- This $136,890 federal Project Grant award from the National Institute of Mental Health (CFDA 93.242 Mental Health Research Grants) supports research at Boston College to enhance the understanding of the neurobiology underlying behavioral responses to danger signals. The key objectives are to identify and describe a dorsal raphe nucleus (DRN) to insula tract responsible for responding to danger signals and executing appropriate behavioral responses in males and females. The research will...
- The federal Project Grant award titled "Synchronous Network Activity in the Maturing Prefrontal Cortex: Mechanistic Impact of Birth Timing and Serotonin" is funded by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242). The $375,927 award, made on May 1, 2025, supports research at the University of Virginia to mechanistically determine the impact of premature birth and serotonin signaling on the development of prefrontal cortex...
- This federal Project Grant award of $125,556 was provided by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242). The award will support research to identify neuronal mechanisms in the medial temporal lobe that underlie avoidance and pursuit behaviors during naturalistic human navigation tasks. The study will leverage a collaboration with epilepsy patients who have implanted electrodes to record single-unit and local field potential...
- The U.S. National Institute of Mental Health (NIMH) awarded a $154,796 Project Grant under the Mental Health Research Grants program (CFDA 93.242) to The Trustees of Princeton University to conduct research on understanding fear relapse and its relationship to anxiety. The key objectives of this 5-year project are to: 1) leverage latent cause inference modeling to quantify individual differences in the computational processes underlying spontaneous recovery of fear during extinction, 2)...
This Project Grant award of $359,433 from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), supports research to investigate the role of the protein FKBP51 in modulating serotonergic function and fear responses. The research aims to increase or decrease FKBP51 expression in serotonin neurons to study its effects on fear learning and extinction. The project will also use a novel serotonin biosensor to measure serotonin release in the amygdala during fear conditioning. The awardee, the Seattle Institute for Biomedical and Clinical Research, will conduct this 2-year project from September 2025 to September 2027.
Generated 10/21/25, 6:45 AM
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $359.4k | 9/24/25 |