This federal Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), will provide $444,125 to George Washington University to investigate the role of serotonergic neurons in alterations to adult social behavior following early life adversity in mice. The research aims to examine the effect of modulating serotonergic neuron activity on social competition in adult mice exposed to early life stress, as well as use fiber...
The National Institute of Mental Health (NIMH) awarded a $267,310 Project Grant (CFDA 93.242 - Mental Health Research Grants) to Trustees of Boston University's Medical Campus to study inhibitory neurotransmission in the prefrontal cortex of rhesus macaques. The research aims to understand how compartment-specific inhibition and laminar circuit dynamics in the lateral prefrontal cortex (LPFC) and anterior cingulate cortex (ACC) contribute to cognitive and emotional disturbances in...
This Project Grant award from the National Institute of Mental Health (NIMH), under the federal Mental Health Research Grants program (CFDA 93.242), provides $1,406,795.00 in funding to Duke University to conduct research on microglial-serotonin interactions in the developing brain. The research aims to determine the mechanisms by which microglia, a type of immune cell, target serotonin-producing neurons for removal in male but not female offspring in conditions of maternal high-fat diet. The...
This federal Project Grant award from the National Institute of Mental Health (NIMH) under CFDA program 93.242 (Mental Health Research Grants) supports research to investigate the impact of species-specific synaptic maturation timing on cortical circuit and behavioral development. The $150,251 award to The Trustees of Columbia University in the City of New York, Health Sciences Division, will utilize CRISPR/Cas9 techniques and electrophysiology to characterize the morphological and functional...
The National Institute of Mental Health (NIMH) awarded a Project Grant under the Mental Health Research Grants program (CFDA 93.242) to the Research Foundation For Mental Hygiene, Inc. (RFMH) for the project "Building a Granular Brain-wide Map of the Serotonin System." The $2,331,491 award, with a project period from May 2024 to February 2029, aims to map the brain-wide projections of serotonergic neurons with single-cell resolution, determine the strength and functional connectivity...
This $392,500 federal Project Grant award was provided by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) to the University of California, Irvine. The grant supports a 5-year research project from January 1, 2025 to December 31, 2029 to study the developmental origins of mental illness, with a focus on understanding how early life adversity impacts the structure and function of the hypothalamus and its contribution to maladaptive...
This Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) supports research at Northeastern University to investigate the role of the hormone allopregnanolone in producing long-term changes in medial prefrontal cortex function after pregnancy. Specifically, the $237,000 award will fund experiments using pharmacological, chemogenetic, and CRISPR/Cas9 manipulations to determine if allopregnanolone-mediated GABA...
This is a Project Grant awarded by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) for the project titled "EARLY LIFE STRESS AND DIFFERENTIAL EFFECTS ON THE MOLECULAR MATURATION OF SPECIFIC SUBTYPES OF BRAIN SEROTONIN NEURONS". The $466,125 grant was awarded on August 25, 2023 to President And Fellows Of Harvard College, acting through the Harvard Medical School Division, to investigate the impact of early life stress and...
This federal Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) provides $682,470 to the University of California, Los Angeles (UCLA) to conduct research on the regulation of cell fate specification in the development of the human cortex. The goal is to elucidate the transcriptional mechanisms driving cortical arealization and laminar identity, which could enhance understanding of the etiology of...
This Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) provides $787,584 to the University of North Carolina at Chapel Hill (UNC-CH) to conduct research on the trajectories of functional brain network organization from birth to early adulthood as predictors of executive function and psychopathology. The key objectives of this 5-year study are to: 1) characterize neural and behavioral trajectories of executive...