This federal Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) provides $444,125 to George Washington University to investigate the role of serotonergic neurons in alterations to adult social behavior following early life adversity. The award will support a 2-year research project using electrophysiology, behavioral assays, and fiber photometry to examine the effects of bidirectionally modulating serotonergic...
This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), will support research aimed at elucidating the immune and neural mechanisms linking airway inflammation and fear regulation. The $463,425 award, effective September 1, 2024, will fund a 5-year study led by the University of Cincinnati. The research will utilize unique mouse models of house dust mite-induced airway inflammation to investigate how IL-17A...
This federal Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $267,310 to support research on the mechanisms of inhibitory neurotransmission in the primate prefrontal cortex. The key objectives are to study the spatial distribution, kinetics, and synaptic physiology of dendritic inhibition in the anterior cingulate cortex (ACC) and lateral prefrontal cortex (LPFC) of rhesus macaques. This research...
This federal Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $715,999 over a period of 5 years beginning September 18, 2024. The award supports research to investigate the role of microglial TREM2 receptor in mediating the hippocampal synaptic and cognitive effects of early life deprivation and enrichment in a mouse model. The research aims to determine if overexpression of TREM2 can correct the...
This Project Grant award, identified as R01MH140184, was issued by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242). The award provides $375,927 to the Rector & Visitors of the University of Virginia (UVA) to conduct research on the impact of premature birth and serotonin signaling on the development of prefrontal cortex circuits and cognitive function. The project aims to use a combination of in vivo electrophysiology,...
The National Institute of Mental Health (NIMH) awarded a Project Grant under the Mental Health Research Grants program (CFDA 93.242) to the Children's Research Institute to study the functional maturation of amygdala circuitry during adolescence. The $629,510 grant, with a project period from Sep 10, 2024 to Aug 31, 2026, will examine the dynamic circuit changes, neuronal responsiveness, and behavioral transitions that occur in the amygdala as adolescents mature into adulthood. The project...
The federal Project Grant award R56MH137986, titled "NEUROCIRCUITRY OF MOTIVATED REWARD-SEEKING AFTER STRESS", was provided by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242). The $606,029 award supports research at the University of Massachusetts Medical School to investigate how the medial habenulo-interpeduncular nucleus (MHB-IPN) brain circuitry mediates the relationship between stress, motivation, and reward-seeking...
This $127,305 Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), supports research to investigate the role of frontal parvalbumin interneuron maturation in the development of attentional abilities from adolescence to adulthood. The research aims to characterize how the maturation of these specific neurons in the anterior cingulate cortex of the frontal lobe is associated with the synchronization of neural...
This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $234,000.00 to investigate how inhibitory synapses in the brain regulate the structure and function of excitatory synapses throughout brain development. The research aims to elucidate the cellular and synaptic mechanisms by which inhibitory GABAergic synapses heterosynaptically modulate excitatory glutamatergic synapse formation and elimination....
This $185,625 Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), supports research on the neural mechanisms underlying socially transmitted aggression in mice. The primary objectives are to: 1) investigate the function of medial amygdala (MeApv) neurons in socially transmitted aggression using chemogenetics, and 2) examine the role of synaptic plasticity at MeApv-VMHvl synapses in modulating socially transmitted...