Project Grant R21MH136380
- The National Institute of Mental Health awarded the President and Fellows of Harvard College, through its Harvard T.H. Chan School of Public Health division, $418,000 on August 10, 2026, to identify epigenetic biomarkers that predict the risk and progression of depression among young adolescents under the Mental Health Research Grants program (CFDA 93.242). The recipient will investigate how DNA methylation and microRNA expression mediate the effects of early life stress on adolescent...
- The National Institute of Mental Health awarded New York University $1.694 million on June 5, 2026, under the Mental Health Research Grants program (CFDA 93.242) to conduct bioinformatic and experimental research on long non-coding RNAs (lncRNAs) in stress response and psychiatric disorder resilience. The research integrates genetic, transcriptional, and epigenetic datasets to identify lncRNAs mediating stress susceptibility and resilience in the brain. The project involves two primary aims:...
- The National Institute of Mental Health awarded The Johns Hopkins University $538,657 on July 15, 2026, under the Mental Health Research Grants program (CFDA 93.242) to develop Neural Navigator, a standardized platform for quantifying circuit pathophysiology in patient-derived cerebral organoids using multi-electrode array recordings and machine learning-based modeling to decode psychiatric disorder signatures in schizophrenia and bipolar disorder. The project aims to establish reproducible...
- The National Institute of Mental Health awarded Research Foundation For Mental Hygiene, Inc. (operating through its New York State Psychiatric Institute division) $818,498 on August 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate how individual differences in hippocampal gene expression modify susceptibility and resilience to depression following early adversity in adolescents. The research will determine whether innate variation in expression of adversity-,...
- The National Institute of Mental Health awarded $1.579 million to the Research Foundation For Mental Hygiene, Inc., operating as the New York State Psychiatric Institute, on July 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to fund basic neuroscience research into the circuit mechanisms by which early-life adversity produces sustained reward deficits. The research examines how childhood trauma—including abuse, neglect, and chronic stress—alters neural circuits governing...
- The National Institute of Mental Health awarded Scripps Research Institute $878,601 on April 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to support structural remodeling of neural circuits via multisynaptic boutons. The research uses three-dimensional electron microscopy at nanometer resolution to reconstruct neuronal connectomes, individual synapses, and glia in the mammalian brain. The work combines 3D-EM with chemogenetic techniques for labeling cellular ensembles...
- The National Institute of Mental Health awarded The Johns Hopkins University $427,625 on May 15, 2026, under the Mental Health Research Grants program (CFDA 93.242) to develop chemical-based molecular tools that enable rapid inactivation of target proteins in specific neuron types during memory consolidation without genetic modification. The project, titled "CHEMI-KNOCK: Achieving Rapidly Inducible Loss-of-Function in Live Animal Brains During Memory Consolidation," addresses the gap...
- The National Institute of Mental Health awarded Northeastern University $157,500 on September 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to explore the role of microglia in developmental effects of early life adversity on prefrontal cortex glutamate receptor development. The research investigates how microglia, resident immune cells of the brain, drive changes in NMDA receptor expression in adolescents exposed to early life adversity such as maternal separation. Prior...
- The National Institute of Mental Health awarded the University of Mississippi Medical Center $156,576 on December 15, 2025, under the Mental Health Research Grants program (CFDA 93.242) to investigate transcriptional and epigenetic differences in postmortem brain tissue that correspond with impulsive behavior in mood disorders. The recipient will analyze transcriptomic and epigenetic variation in the dorsolateral prefrontal cortex, orbitofrontal cortex, anterior cingulate cortex, and nucleus...
- The National Institute of Mental Health awarded The Trustees of Columbia University in the City of New York $534,191 on April 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to develop robust fine-mapping tools for genetic discovery in neuropsychiatric traits using deep phenotype data from diverse populations. The project addresses the challenge of understanding genetic causes of complex neuropsychiatric conditions including autism spectrum disorders, bipolar disorder, and...
The National Institute of Mental Health awarded The Johns Hopkins University $384,245 on August 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to develop DNA probes and modified extracellular vesicles as therapeutic tools to reverse stress-induced epigenetic changes in the brain. The project addresses the role of chronic stress and cortisol exposure in causing epigenetic modifications that disrupt genes critical for brain function and neurodevelopment, contributing to psychiatric disorders including depression, anxiety, and bipolar disorder. The award funds development and testing of single-stranded DNA probes designed to reverse epigenetic changes at specific genomic locations and engineered lipid-based extracellular vesicles capable of packaging and delivering these probes to the brain. The research proposes to test whether epigenetic changes induced by stress can be reversed in an animal model using these novel approaches as a potentially powerful translational tool for treating psychiatric disorders. The period of performance runs from August 1, 2026, through July 31, 2028. Work is performed in Maryland. This award is a Project Grant, the assistance type used by NIMH for research projects with specified project periods not to exceed five years.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $384.2k | 7/29/26 |